PPP2CA anticorps (AA 101-200) (Alexa Fluor 594)

N° du produit ABIN2805496

Détail du produit anti-PPP2CA anticorps (Alexa Fluor 594)

Antigène: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Épitope: AA 101-200

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPP2CA est conjugé à/à la Alexa Fluor 594

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Rat

Homologie: Human,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PP2CA

Isotype: IgG

Information d'application

Indications d'application: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PPP2CA

Antigène: PPP2CA (Protein Phosphatase 2, Catalytic Subunit, alpha Isozyme (PPP2CA))

Autre désignation: PP2CA (PPP2CA Produits)

Synonymes: anticorps PP2Ac, anticorps PP2CA, anticorps PP2Calpha, anticorps RP-C, anticorps PP2A, anticorps R75353, anticorps Pp2a1, anticorps pp2ac, anticorps zgc:110641, anticorps protein phosphatase 2 catalytic subunit alpha, anticorps protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform, anticorps protein phosphatase 2, catalytic subunit, alpha isozyme, anticorps protein phosphatase 2 catalytic subunit alpha L homeolog, anticorps protein phosphatase 2, catalytic subunit, beta isozyme, anticorps serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, anticorps PPP2CA, anticorps Ppp2ca, anticorps ppp2ca.L, anticorps ppp2cb, anticorps LOC471633, anticorps ppp2ca

Sujet:

Synonyms: Mpp alpha, PP2C alpha, PP2C-alpha, PP2CA, PPM 1A, PPM1A, PPM1A_HUMAN, PPPM1A, Protein phosphatase 1A formerly 2C magnesium dependent alpha isoform, Protein phosphatase 1A, Protein phosphatase 1A magnesium dependent alpha, Protein phosphatase 2C alpha, Protein phosphatase 2C alpha isoform, Protein phosphatase 2C isoform alpha, Protein phosphatase IA, Protein phosphatase 2C isoform alpha, IA antibody.

Background: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

ID gène: 5494

Pathways: Signalisation PI3K-Akt, Mitotic G1-G1/S Phases, Hepatitis C, Toll-Like Receptors Cascades