beta 2 Adrenergic Receptor (BAR2) (AA 1-30), (N-Term) anticorps

N° du produit ABIN391396

Détail du produit

Antigène: beta 2 Adrenergic Receptor (BAR2)

Épitope: AA 1-30, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Western Blotting (WB)

Specificité: This BAR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7~37 amino acids from the N-terminal region of human BAR2.

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This beta 2 Adrenergic Receptor (BAR2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human beta 2 Adrenergic Receptor (BAR2).

Clone: RB10325

Isotype: Ig Fraction

Information d'application

Indications d'application: WB = 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.42 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Référence

Simkins, Crawford, Goudreau, Lookingland, Kaplan: "Enhanced humoral immunity in mice lacking CB1 and CB2 receptors (Cnr1-/-/Cnr2-/- mice) is not due to increased splenic noradrenergic neuronal activity." dans: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, Vol. 9, Issue 4, pp. 544-57, (2014) (PubMed).

Rodrigues, Tran, Fortes, Schmid-Schönbein: "Matrix metalloproteinases cleave the beta2-adrenergic receptor in spontaneously hypertensive rats." dans: American journal of physiology. Heart and circulatory physiology, Vol. 299, Issue 1, pp. H25-35, (2010) (PubMed).

Détail du antigène

Antigène: beta 2 Adrenergic Receptor (BAR2)

Sujet: This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
Synonyms: Beta-2 adrenoceptor, Beta-2 adrenoreceptor, ADRB2, ADRB2R, B2AR

Poids moléculaire: 46426 DA

ID gène: 154

NCBI Accession: NP_000015