pADPR anticorps

N° du produit ABIN2854260

Détail du produit

Antigène: pADPR

Reactivité: Toutes les espèces

Hôte: Poulet

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Attributs du produit: Recognizes DNA-damage and apoptosis related poly-ADP ribosylated proteins and poly (ADP-ribose) polymer

Purification: Immunofractionation

Immunogène: poly(ADP-ribose)

Isotype: IgY

Information d'application

Indications d'application: WB 1 µg/mL,
IH 1 µg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4 with 0,05 % sodium azides

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze/thaw cycles.

Stock: -20 °C

Stockage commentaire: Stable for 1 year from date of shipment when stored at -20 °C or -70 °C. Stable for at least 1 month at 4 °C.

Référence

Vyas, Chesarone-Cataldo, Todorova, Huang, Chang: "A systematic analysis of the PARP protein family identifies new functions critical for cell physiology." dans: Nature communications, Vol. 4, pp. 2240, (2013) (PubMed).

Yeh, Sbodio, Tsun, Luo, Chi: "Insulin-stimulated exocytosis of GLUT4 is enhanced by IRAP and its partner tankyrase." dans: The Biochemical journal, Vol. 402, Issue 2, pp. 279-90, (2007) (PubMed).

Xiao, Chen, Zsengellér, Li, Kiss, Kollai, Szabó: "Poly(ADP-Ribose) polymerase promotes cardiac remodeling, contractile failure, and translocation of apoptosis-inducing factor in a murine experimental model of aortic banding and heart failure." dans: The Journal of pharmacology and experimental therapeutics, Vol. 312, Issue 3, pp. 891-8, (2005) (PubMed).

Cover, Fickert, Knight, Fuchsbichler, Farhood, Trauner, Jaeschke: "Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 84, Issue 1, pp. 201-8, (2005) (PubMed).

Chang, Coughlin, Mitchison: "Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function." dans: Nature cell biology, Vol. 7, Issue 11, pp. 1133-9, (2005) (PubMed).

Chang, Jacobson, Mitchison: "Poly(ADP-ribose) is required for spindle assembly and structure." dans: Nature, Vol. 432, Issue 7017, pp. 645-9, (2004) (PubMed).

Szabó, Pacher, Zsengellér, Vaslin, Komjáti, Benkö, Chen, Mabley, Kollai: "Angiotensin II-mediated endothelial dysfunction: role of poly(ADP-ribose) polymerase activation." dans: Molecular medicine (Cambridge, Mass.), Vol. 10, Issue 1-6, pp. 28-35, (2004) (PubMed).

Xiao, Chen, Zsengellér, Szabó: "Poly(ADP-ribose) polymerase contributes to the development of myocardial infarction in diabetic rats and regulates the nuclear translocation of apoptosis-inducing factor." dans: The Journal of pharmacology and experimental therapeutics, Vol. 310, Issue 2, pp. 498-504, (2004) (PubMed).

Szabó, Soós, Bährle, Zsengellér, Flechtenmacher, Hagl, Szabó: "Role of poly(ADP-ribose) polymerase activation in the pathogenesis of cardiopulmonary dysfunction in a canine model of cardiopulmonary bypass." dans: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 25, Issue 5, pp. 825-32, (2004) (PubMed).

Szabó, Soós, Mandera, Heger, Flechtenmacher, Seres, Zsengellér, Sack, Szabó, Hagl: "Mesenteric injury after cardiopulmonary bypass: role of poly(adenosine 5'-diphosphate-ribose) polymerase." dans: Critical care medicine, Vol. 32, Issue 12, pp. 2392-7, (2004) (PubMed).

Obrosova, Pacher, Szabó, Zsengeller, Hirooka, Stevens, Yorek: "Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications." dans: Diabetes, Vol. 54, Issue 1, pp. 234-42, (2004) (PubMed).

Détail du antigène

Antigène: pADPR

Sujet: Synonyms: poly(ADP-ribose)
Poly(ADP-ribose) or pADPr is a polymer synthesized by a class of enzymes named poly(ADP-ribose) polymerase (PARP). Using NAD+ as substrate, PARP catalyzes the formation of the polymer pADPr, with chain lengths ranging from 2 to 300 residues, containing approximately 2 % branching in the chain. pADPr becomes attached to nuclear proteins, and to PARP itself (automodification).