EGFR anticorps

N° du produit ABIN285476

Détail du produit anti-EGFR anticorps

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reactivité: Humain

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp EGFR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunochromatography (IC)

Réactivité croisée: Souris, Rat (Rattus), Dindon

Purification: purified

Immunogène: EGFR antibody was raised in sheep using a synthetic 20 amino acid peptide of human EGFr representing a portion of the internal domain proximal to a phosphorylation region as the immunogen.

Information d'application

Indications d'application: WB: 10-50 µg/mL, IC: 25-100 µg/mL, IHC-P: 5 µg/mL, IP: 10-12 µg/mL, WB: 10-50 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: Protein G purified and supplied in PBS, pH 7.2.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: -20 °C

Stockage commentaire: Aliquot and store at -20 °C.

Références pour anticorps anti-EGFR (ABIN285476)

Saveri, De Luca, Nisi, Pisciotta, Romano, Piscosquito, Reilly, Polke, Cavallaro, Fabrizi, Fossa, Cichero, Lombardi, Lauria, Magri, Taroni, Pareyson, Bucci: "Charcot-Marie-Tooth Type 2B: A New Phenotype Associated with a Novel RAB7A Mutation and Inhibited EGFR Degradation." dans: Cells, Vol. 9, Issue 4, (2020) (PubMed).

Larios, Mercier, Roux, Gruenberg: "ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes." dans: The Journal of cell biology, Vol. 219, Issue 3, (2020) (PubMed).

Ripoll, Heiligenstein, Hurbain, Domingues, Figon, Petersen, Dennis, Houdusse, Marks, Raposo, Delevoye: "Myosin VI and branched actin filaments mediate membrane constriction and fission of melanosomal tubule carriers." dans: The Journal of cell biology, Vol. 217, Issue 8, pp. 2709-2726, (2019) (PubMed).

Matsui, Jiang, Nakano, Sakamaki, Yamamoto, Mizushima: "Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17." dans: The Journal of cell biology, Vol. 217, Issue 8, pp. 2633-2645, (2019) (PubMed).

Keir, Chandramohan, Hemphill, Grandal, Melander, Pedersen, Horak, Kragh, Desjardins, Friedman, Bigner: "Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models." dans: Journal of neuro-oncology, Vol. 138, Issue 3, pp. 489-498, (2019) (PubMed).

Wenzel, Schultz, Schink, Pedersen, Nähse, Carlson, Brech, Stenmark, Raiborg: "Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation." dans: Nature communications, Vol. 9, Issue 1, pp. 2932, (2018) (PubMed).

Torgersen, Klokk, Kavaliauskiene, Klose, Simons, Skotland, Sandvig: "The anti-tumor drug 2-hydroxyoleic acid (Minerval) stimulates signaling and retrograde transport." dans: Oncotarget, Vol. 7, Issue 52, pp. 86871-86888, (2018) (PubMed).

Filipek, de Araujo, Vogel, De Smet, Eberharter, Rebsamen, Rudashevskaya, Kremser, Yordanov, Tschaikner, Fürnrohr, Lechner, Dunzendorfer-Matt, Scheffzek, Bennett, Superti-Furga, Lindner, Stasyk, Huber: "LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning." dans: The Journal of cell biology, Vol. 216, Issue 12, pp. 4199-4215, (2017) (PubMed).

Fujita, Huang, Lin, Groulx, Jean, Nguyen, Kuchitsu, Koyama-Honda, Mizushima, Fukuda, Kiger: "Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy." dans: eLife, Vol. 6, (2017) (PubMed).

Lo Cicero, Delevoye, Gilles-Marsens, Loew, Dingli, Guéré, André, Vié, van Niel, Raposo: "Exosomes released by keratinocytes modulate melanocyte pigmentation." dans: Nature communications, Vol. 6, pp. 7506, (2016) (PubMed).

Matsui, Noguchi, Fukuda: "Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts." dans: The Journal of biological chemistry, Vol. 289, Issue 20, pp. 13986-95, (2014) (PubMed).

Rønning, Pedersen, Madshus, Stang: "CIN85 regulates ubiquitination and degradative endosomal sorting of the EGF receptor." dans: Experimental cell research, Vol. 317, Issue 13, pp. 1804-16, (2011) (PubMed).

Larsen, Stockhausen, Poulsen: "Cell adhesion and EGFR activation regulate EphA2 expression in cancer." dans: Cellular signalling, Vol. 22, Issue 4, pp. 636-44, (2010) (PubMed).

Grøvdal, Johannessen, Rødland, Madshus, Stang: "Dysregulation of Ack1 inhibits down-regulation of the EGF receptor." dans: Experimental cell research, Vol. 314, Issue 6, pp. 1292-300, (2008) (PubMed).

Bertelsen, Breen, Sandvig, Stang, Madshus: "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis." dans: Experimental cell research, Vol. 313, Issue 8, pp. 1696-709, (2007) (PubMed).

Oksvold, Huitfeldt, Langdon: "Identification of 14-3-3zeta as an EGF receptor interacting protein." dans: FEBS letters, Vol. 569, Issue 1-3, pp. 207-10, (2004) (PubMed).

Détails sur EGFR

Antigène: EGFR (Epidermal Growth Factor Receptor (EGFR))

Autre désignation: EGFR (EGFR Produits)

Synonymes: anticorps C-erb, anticorps CG10079, anticorps D-EGFR, anticorps D-Egf, anticorps DEGFR, anticorps DER, anticorps DER flb, anticorps DER/EGFR, anticorps DER/faint little ball, anticorps DER/top, anticorps DER/torpedo, anticorps DER1, anticorps DEgfr, anticorps Degfr, anticorps Der, anticorps DmHD-33, anticorps Dmel\\CG10079, anticorps EFG-R, anticorps EGF-R, anticorps EGFR, anticorps EGFr, anticorps EGfr, anticorps EK2-6, anticorps Egf, anticorps Egf-r, anticorps EgfR, anticorps El, anticorps Elp, anticorps Elp-1, anticorps Elp-B1, anticorps Elp-B1RB1, anticorps HD-33, anticorps TOP, anticorps Torpedo/DER, anticorps Torpedo/Egfr, anticorps c-erbB, anticorps d-egf-r, anticorps dEGFR, anticorps dEGFR1, anticorps dEgfr, anticorps der, anticorps egfr, anticorps flb, anticorps l(2)05351, anticorps l(2)09261, anticorps l(2)57DEFa, anticorps l(2)57EFa, anticorps l(2)57Ea, anticorps mor1, anticorps top, anticorps top/DER, anticorps top/flb, anticorps torpedo/Egfr, anticorps torpedo/egfr, anticorps EGFR12, anticorps EGFR15, anticorps egfr1, anticorps Erbb2, anticorps ERBB, anticorps ERBB1, anticorps HER1, anticorps PIG61, anticorps mENA, anticorps ErbB-1, anticorps Errp, anticorps 9030024J15Rik, anticorps AI552599, anticorps Erbb, anticorps Errb1, anticorps Wa5, anticorps wa-2, anticorps wa2, anticorps epidermal growth factor receptor, anticorps Epidermal growth factor receptor, anticorps epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian), anticorps EGFR, anticorps Egfr, anticorps egfra, anticorps egfr1, anticorps LOC5564544

Sujet: The epidermal growth factor receptor (EGFR) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor alpha (TGF alpha).

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins