CBFA2T2 anticorps (C-Term)

N° du produit ABIN2856638

Détail du produit anti-CBFA2T2 anticorps

Antigène: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBFA2T2 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Réactivité croisée: Souris, Poulet, Rat (Rattus)

Réactivité croisée (Details): Mouse (95 %), Chicken (80 %), Rat (95 %)

Attributs du produit: Rabbit polyclonal antibody to CBFA2T2 (core-binding factor, runt domain, alpha subunit 2, translocated to, 2)
MTGR1 antibody [C1C3]

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the C-terminus region of human MTGR1. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: Suggested dilution Reference ICC/IF 1:100-1:1000* Western blot 1:500-1:3000* Not tested in other applications. *Optimal dilutions/concentrations should be determined by the researcher.Suggested dilutionReferenceICC/IF1:100-1:1000* Western blot1:500-1:3000*

Commentaires:

Positive Control: 293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.1M Tris, 0.1M Glycine, 10 % Glycerol ( pH 7). 0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur CBFA2T2

Antigène: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Autre désignation: CBFA2T2 (CBFA2T2 Produits)

Synonymes: anticorps MTGR1, anticorps A430091M07, anticorps C330013D05Rik, anticorps Cbfa2t2h, anticorps EHT, anticorps ZMYND3, anticorps p85, anticorps XETOR, anticorps cbfa2t2-a, anticorps CBFA2/RUNX1 translocation partner 2, anticorps core-binding factor, runt domain, alpha subunit 2, translocated to, 2 (human), anticorps CBFA2/RUNX1 translocation partner 2 L homeolog, anticorps Cbfa2t2, anticorps CBFA2T2, anticorps cbfa2t2.L

Sujet: In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

Cellular Localization: Nucleus

Poids moléculaire: 67 kDa

ID gène: 9139