NR0B2 anticorps (AA 1-257)

N° du produit ABIN6218962

Détail du produit anti-NR0B2 anticorps

Antigène: NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))

Épitope: AA 1-257

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR0B2 est non-conjugé

Application: Western Blotting (WB)

Séquence: MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC APHRTCREAL DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL AQDAVTFEVA EAPVPSILKK ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ CCLESFWSLE LSPKEYACLK GTILFNPDVP GLQAASHIGH LQQEAHWVLC EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI IGDVDIAGLL GDMLLLR

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human NR0B2 (NP_068804.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur NR0B2

Antigène: NR0B2 (Nuclear Receptor Subfamily 0, Group B, Member 2 (NR0B2))

Autre désignation: NR0B2 (NR0B2 Produits)

Synonymes: anticorps SHP, anticorps SHP1, anticorps SHP-1, anticorps Shp1, anticorps Shp, anticorps NR0B2-A, anticorps Nr0b2, anticorps SHP-A, anticorps gb:bc058069, anticorps nuclear receptor subfamily 0 group B member 2, anticorps nuclear receptor subfamily 0, group B, member 2, anticorps nuclear receptor subfamily 0, group B, member 2a, anticorps NR0B2, anticorps Nr0b2, anticorps nr0b2a

Sujet: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.,NR0B2,SHP,SHP1,Epigenetics & Nuclear Signaling,Transcription Factors,Nuclear Receptor Signaling,Nuclear hormone receptors,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,NR0B2

Poids moléculaire: 28 kDa

ID gène: 8431

UniProt: Q15466

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway