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VHL anticorps (AA 1-172)
VHL
Reactivité: Humain
WB, IHC, IF
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN3020968
Détail du produit anti-VHL anticorps
(cache)
Antigène
Voir toutes VHL Anticorps
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Épitope
Tous les épitopes à travers VHL Anticorps.
AA 1-172
Reactivité
Toutes les réactivités sur VHL Anticorps
Humain
Hôte
Toutes les hôtes sur VHL Anticorps
Lapin
Clonalité
Toutes les clonalités sur VHL Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers VHL Anticorps
Cet anticorp VHL est non-conjugé
Application
Tous les applications à travers VHL Anticorps.
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Séquence
MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRVYTLKER CLQVVRSLVK PENYRRLDIV RSLYEDLEDH PNVQKDLERL TQERIAHQRM GD
Réactivité croisée
Humain, Souris, Rat
Attributs du produit
Polyclonal Antibodies
Immunogène
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human VHL (NP_937799.1).
Isotype
IgG
Top Product
Discover our top product VHL Anticorps primaire
Alternatives
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Information d'application
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Indications d'application
WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
Restrictions
For Research Use only
Stockage
(cache)
Format
Liquid
Buffer
PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid freeze / thaw cycles
Stock
-20 °C
Stockage commentaire
Store at -20°C. Avoid freeze / thaw cycles.
Références pour anticorps anti-VHL (ABIN3020968)
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Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao : "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL). " dans: The Journal of biological chemistry , Vol. 291 , Issue 49 , pp. 25692-25705 , (2017 ) (PubMed ).
Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao : "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. " dans: Journal of immunology (Baltimore, Md. : 1950) , Vol. 195 , Issue 4 , pp. 1782-90 , (2015 ) (PubMed ).
Wang, Zhang, Ji, Liu, Ouyang, Xiao : "The von hippel-lindau protein suppresses androgen receptor activity. " dans: Molecular endocrinology (Baltimore, Md.) , Vol. 28 , Issue 2 , pp. 239-48 , (2015 ) (PubMed ).
Détails sur VHL
(cache)
Antigène
VHL
(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Autre désignation
VHL (VHL Produits )
Synonymes
anticorps HRCA1, anticorps RCA1, anticorps VHL1, anticorps pVHL, anticorps BcDNA:RH61560, anticorps CG13221, anticorps DVhl, anticorps Dmel\\CG13221, anticorps Dvhl, anticorps VHL, anticorps d-VHL, anticorps d-vhl, anticorps dVHL, anticorps dmVHL, anticorps vhl, anticorps rca1, anticorps vhl1, anticorps hrca1, anticorps zgc:158722, anticorps Vhlh, anticorps von Hippel-Lindau tumor suppressor, anticorps von Hippel-Lindau, anticorps von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase, anticorps von Hippel-Lindau disease tumor suppressor, anticorps VHL, anticorps Vhl, anticorps vhl, anticorps CpipJ_CPIJ009992
Sujet
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.,VHL,HRCA1,RCA1,VHL1,pVHL,PVHL,Epigenetics & Nuclear Signaling,Cancer,Tumor suppressors,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Cell cycle inhibitors,Cell differentiation,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,Cardiovascular,Angiogenesis,VHL
Poids moléculaire
18 kDa/19 kDa/24 kDa
ID gène
7428
UniProt
P40337
Pathways
Tube Formation , Signaling Events mediated by VEGFR1 and VEGFR2 , Ubiquitin Proteasome Pathway
Vus récemment
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