BTRC anticorps (AA 50-340)

N° du produit ABIN3022334

Cet anticorps Lapin Polyclonal détecte spécifiquement BTRC dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour BTRC anticorps (AA 50-340) (ABIN3022334)

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BTRC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-BTRC anticorps

Épitope: AA 50-340

Séquence: AFQNSSERED CNNGEPPRKI IPEKNSLRQT YNSCARLCLN QETVCLASTA MKTENCVAKT KLANGTSSMI VPKQRKLSAS YEKEKELCVK YFEQWSESDQ VEFVEHLISQ MCHYQHGHIN SYLKPMLQRD FITALPARGL DHIAENILSY LDAKSLCAAE LVCKEWYRVT SDGMLWKKLI ERMVRTDSLW RGLAERRGWG QYLFKNKPPD GNAPPNSFYR ALYPKIIQDI ETIESNWRCG RHSLQRIHCR SETSKGVYCL QYDDQKIVSG LRDNTIKIWD KNTLECKRIL T

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 50-340 of human beta-TrCP/BTRC (NP_378663.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid freeze / thaw cycles

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur BTRC

Antigène: BTRC (beta-Transducin Repeat Containing (BTRC))

Autre désignation: BTRC

Sujet: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class, in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.,BTRC,BETA-TRCP,FBW1A,FBXW1,FBXW1A,FWD1,bTrCP,bTrCP1,betaTrCP,Beta-TRCP,Signal Transduction,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Ubiquitin,Ubiquitin-Proteasome Signaling Pathway,Hedgehog Signaling Pathway,Wnt/β-Catenin Signaling Pathway,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,BTRC

Poids moléculaire: 65 kDa/68 kDa

ID gène: 8945

UniProt: Q9Y297

Pathways: Cycle Cellulaire, Signalisation Hedgehog