HMGB1 anticorps (AA 100-200)

N° du produit ABIN3023358

Cet anticorps Lapin Polyclonal détecte spécifiquement HMGB1 dans WB et IHC. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour HMGB1 anticorps (AA 100-200) (ABIN3023358)

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HMGB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-HMGB1 anticorps

Épitope: AA 100-200

Séquence: SAFFLFCSEY RPKIKGEHPG LSIGDVAKKL GEMWNNTAAD DKQPYEKKAA KLKEKYEKDI AAYRAKGKPD AAKKGVVKAE KSKKKKEEEE DEEDEEDEEE E

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human HMGB1 (NP_002119.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Références pour anticorps anti-HMGB1 (ABIN3023358)

Seth, Kimono, Alhasson, Sarkar, Albadrani, Lasley, Horner, Janulewicz, Nagarkatti, Nagarkatti, Sullivan, Chatterjee: "Increased butyrate priming in the gut stalls microbiome associated-gastrointestinal inflammation and hepatic metabolic reprogramming in a mouse model of Gulf War Illness." dans: Toxicology and applied pharmacology, Vol. 350, pp. 64-77, (2018) (PubMed).

Yao, Zhao, Tang, Xiong, Zhao, Liu, Dong, Zou, Cai: "Blockade of β-catenin signaling attenuates toluene diisocyanate-induced experimental asthma." dans: Allergy, Vol. 72, Issue 4, pp. 579-589, (2017) (PubMed).

Chen, Yu, Yuan, Zhang, Fan, Yuan, Zhang, Yao: "Enriched housing promotes post-stroke functional recovery through astrocytic HMGB1-IL-6-mediated angiogenesis." dans: Cell death discovery, Vol. 3, pp. 17054, (2017) (PubMed).

Détails sur HMGB1

Antigène: HMGB1 (High Mobility Group Box 1 (HMGB1))

Autre désignation: HMGB1

Sujet: This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.,HMG-1,HMG1,HMG3,SBP-1,HMGB1,Epigenetics & Nuclear Signaling,Histones,RNA Binding,Cell Biology & Developmental Biology,Apoptosis,HMGB1

Poids moléculaire: 24 kDa

ID gène: 3146

UniProt: P09429

Pathways: Signalisation p53, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, Inflammasome