FBXO5 anticorps (N-Term)
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- Antigène Voir toutes FBXO5 Anticorps
- FBXO5 (F-Box Protein 5 (FBXO5))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FBXO5 est non-conjugé
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Application
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- Protein G affinity chromatography
- Immunogène
- A human partial recombinant N-terminal protein fragment was used as the immunogen for the EMI-1 antibody.
- Clone
- FBXP5
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FBXO5 Anticorps primaire
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- Indications d'application
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Optimal dilution of the EMI-1 antibody should be determined by the researcher.
1. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 minutes
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Prediluted IHC only format : incubate for 30 min at RT (2) - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Prediluted in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, *For IHC use only*
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Store the EMI-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- Antigène
- FBXO5 (F-Box Protein 5 (FBXO5))
- Autre désignation
- EMI-1 (FBXO5 Produits)
- Synonymes
- anticorps EMI1, anticorps FBX5, anticorps Fbxo31, anticorps 2510044I10Rik, anticorps C85305, anticorps Emi1, anticorps emi1, anticorps fc65h02, anticorps wu:fc65h02, anticorps wu:fe06e07, anticorps wu:fz79f03, anticorps zgc:136397, anticorps zgc:158541, anticorps fbx5, anticorps Fbxo5, anticorps ACYPI007854, anticorps fbxo5, anticorps F-box protein 5, anticorps F-box only protein 5, anticorps F-box protein 5 L homeolog, anticorps F-box protein 5 S homeolog, anticorps FBXO5, anticorps Fbxo5, anticorps fbxo5, anticorps fbxo5.L, anticorps fbxo5.S
- Sujet
- Early Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.
- Pathways
- Mitotic G1-G1/S Phases
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