FOXA1 anticorps (AA 372-472)

N° du produit ABIN3026288

Détail du produit anti-FOXA1 anticorps

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Épitope: AA 372-472

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXA1 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Protein G affinity chromatography

Immunogène: A human partial recombinant protein corresponding to amino acids 372-472 was used as the immunogen for this FOXA1 antibody.

Clone: FHBA1-1

Isotype: IgG

Information d'application

Indications d'application: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the FOXA1 antibody to be titered up or down for optimal performance.

1. Staining of FFPE tissue is enhanced by boiling sections in 10  mM Tris with 1  mM EDTA,  pH 9 for 10-20 min followed by cooling at RT for 20 min.\. FACS: 0.5-1 μg/10^6 cells,IF: 1-2 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT (1)

Restrictions: For Research Use only

Stockage

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the FOXA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).

Détails sur FOXA1

Antigène: FOXA1 (Forkhead Box A1 (FOXA1))

Autre désignation: FOXA1 (FOXA1 Produits)

Synonymes: anticorps HNF3A, anticorps TCF3A, anticorps Hnf-3a, anticorps Hnf3a, anticorps Tcf-3a, anticorps Tcf3a, anticorps fkd7, anticorps forkhead-7, anticorps HNF3-alpha, anticorps HNF3alpha, anticorps fkh2, anticorps foxa1, anticorps hnf3a, anticorps tFoxA1, anticorps tcf3a, anticorps xfkh2, anticorps fkh, anticorps FOXA1, anticorps Ci-fkh, anticorps HNF-3a, anticorps forkhead box A1, anticorps forkhead box A1 S homeolog, anticorps forkhead homolog, anticorps forkhead box A1 L homeolog, anticorps FOXA1, anticorps Foxa1, anticorps foxa1, anticorps foxa1.S, anticorps fkh, anticorps foxa1.L

Sujet: The transcription factor Forkhead-box A1, also known as hepatocyte nuclear factor 3-alpha, is a member of the FOX class of transcription factors. HNF-1 (alpha and beta), HNF-3 (alpha, beta and gamma), HNF-4 (alpha and gamma), and HNF-6 compose, in part, a homeoprotein family designated the hepatocyte nuclear factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. FOXA1 is expressed in normal breast ductal epithelium and other epithelium in different organs, such as lung, pancreas, bladder, prostate, and colon. Recently, FOXA1 has been shown to be a major determinant of estrogen-ER activity and endocrine response in breast cancer cells. Its expression correlates with estrogen receptor (ER)-positivity, especially in luminal subtype A breast cancers, which is associated with favorable prognosis. FOXA1 is useful in the sub-classification of breast carcinomas.

ID gène: 3169

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Carbohydrate Homeostasis