Vitamin D Receptor anticorps (C-Term)

N° du produit ABIN3029598

Détail du produit anti-Vitamin D Receptor anticorps

Antigène: Vitamin D Receptor (VDR)

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Vitamin D Receptor est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human Vitamin D Receptor (DLRSLNEEHSKQYRCL) was used as the immunogen for this VDR antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the VDR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Vitamin D Receptor

Antigène: Vitamin D Receptor (VDR)

Autre désignation: VDR (Vitamin D Receptor) (VDR Produits)

Synonymes: anticorps vdrbeta, anticorps vdr0, anticorps LOC100136219, anticorps NR1I1-B, anticorps gb:dq017633, anticorps vdr-b, anticorps Ci-VDR-b, anticorps VDR, anticorps LOC100221284, anticorps vdr-A, anticorps xVDR, anticorps Nr1i1, anticorps vdr, anticorps NR1I1, anticorps PPP1R163, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor, anticorps vitamin D receptor, anticorps vitamin D3 receptor A, anticorps vitamin D receptor b, anticorps nuclear receptor VDR-b, anticorps vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog, anticorps vitamin D (1,25-dihydroxyvitamin D3) receptor, anticorps vitamin D receptor a, anticorps vdr, anticorps vdr0, anticorps VDR, anticorps LOC100136219, anticorps vdrb, anticorps vdr-b, anticorps vdr.L, anticorps Vdr, anticorps vdra

Classe de substances: Chemical

Sujet: Vitamin D Receptor, also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al.(2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB(TFIIB). A natural polymorphic variant of the receptor, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor. Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.

UniProt: P11473

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway