CSF3R anticorps (Middle Region)

N° du produit ABIN3029704

Détail du produit anti-CSF3R anticorps

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSF3R est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human CSF3R (EPWQPGLHINQKCELRHK) was used as the immunogen for this CSF3R antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the CSF3R antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CSF3R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur CSF3R

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Autre désignation: CSF3R Colony Stimulating Factor 3 Receptor (CSF3R Produits)

Synonymes: anticorps CD114, anticorps GCSFR, anticorps Cd114, anticorps Csfgr, anticorps G-CSF-R, anticorps G-CSFR, anticorps CSF3R, anticorps gcsfr, anticorps cd114, anticorps colony stimulating factor 3 receptor, anticorps colony stimulating factor 3 receptor (granulocyte), anticorps colony stimulating factor 3 receptor L homeolog, anticorps granulocyte colony-stimulating factor receptor, anticorps CSF3R, anticorps Csf3r, anticorps csf3r, anticorps csf3r.L, anticorps LOC100433338

Sujet: Colony-Stimulating Factor 3 Receptor, Granulocyte also known as GCSFR or CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al.(1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al.(2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

UniProt: Q99062