ABCC4
Reactivité: Humain
WB
Hôte: Lapin
Polyclonal
RB17763
unconjugated
Indications d'application
Titration of the MRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
Restrictions
For Research Use only
Buffer
0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
Stock
-20 °C
Stockage commentaire
The lyophilized MRP4 antibody can be stored at 4°C to -20°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Antigène
ABCC4
(ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4 (ABCC4))
anticorps EST170205, anticorps MOAT-B, anticorps MOATB, anticorps MRP4, anticorps D630049P08Rik, anticorps Mrp4, anticorps ATP binding cassette subfamily C member 4, anticorps multidrug resistance-associated protein 4, anticorps ATP-binding cassette, sub-family C (CFTR/MRP), member 4, anticorps ABCC4, anticorps LOC515333, anticorps LOC616707, anticorps LOC695407, anticorps abcc4, anticorps Abcc4
Sujet
ABCC4 (ATP-binding cassette, subfamily c, member 4) also known as MRP4 (Multidrug resistance associated protein 4) or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4/MRP4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MPR4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of its activity or knockdown of the protein via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.