Cathepsin B anticorps (AA 80-333)

N° du produit ABIN3030330

Détail du produit anti-Cathepsin B anticorps

Antigène: Cathepsin B (CTSB)

Épitope: AA 80-333

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cathepsin B est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Human partial recombinant protein (AA 80-333) was used as the immunogen for this Cathepsin B antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Cathepsin B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Cathepsin B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur Cathepsin B

Antigène: Cathepsin B (CTSB)

Autre désignation: Cathepsin B (CTSB Produits)

Synonymes: anticorps APPS, anticorps CPSB, anticorps CB, anticorps apps, anticorps cpsb, anticorps LOC692390, anticorps CTSB, anticorps cathepsin B, anticorps cathepsin B S homeolog, anticorps CTSB, anticorps Ctsb, anticorps ctsb.S, anticorps LOC692390

Sujet: Cathepsin B is an enzymatic protein belonging to the peptidase or protease families. In humans, it is coded by the CTSB gene. The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. Cathepsin B was once suspected as a candidate protease participating in the conversion of beta-amyloid precursor protein into the amyloid plaques found in Alzheimers disease patients. However, this function is now known to be mediated by BACE1 protease. It is now thought that Cathepsin B can degrade beta-amyloid precursor protein into harmless fragments. Thus, it is conceivable cathepsin B may play a pivotal role in the natural defense against Alzheimers disease. Overexpression has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene.

ID gène: 1508

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades