CYP11A1 anticorps (C-Term)

N° du produit ABIN3030677

Détail du produit anti-CYP11A1 anticorps

Antigène: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP11A1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the C-terminus of human CYP11A1 (ISFTFWPFNQEATQQ) was used as the immunogen for this CYP11A1 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the CYP11A1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the CYP11A1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur CYP11A1

Antigène: CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))

Autre désignation: CYP11A1 (CYP11A1 Produits)

Synonymes: anticorps CYP11A, anticorps CYP11A1, anticorps CYPXIA1, anticorps P450SCC, anticorps Cyp11a, anticorps Cypxia1, anticorps D9Ertd411e, anticorps P450scc, anticorps Scc, anticorps cscc, anticorps P450(scc), anticorps SSC, anticorps cytochrome P450 family 11 subfamily A member 1, anticorps cholesterol side-chain cleavage enzyme, mitochondrial-like, anticorps cytochrome P450 cholesterol side-chain cleavage, anticorps cytochrome P450, family 11, subfamily a, polypeptide 1, anticorps cytochrome P450, family 11, subfamily A, polypeptide 1, anticorps CYP11A1, anticorps LOC101827747, anticorps Cyp11a1

Sujet: Cytochrome p450, family 11, subfamily A, polypeptide 1), also called P450SCC, P450C11A1 or CYP11A, is a mitochondrial enzyme associated with the conversion of cholesterol to pregnenolone. CYP11A1 is a member of the cytochrome P450 superfamily of enzymes. The gene is mapped on 15q24.1. Expression of the CYP11A1 gene may play a role in skin physiology and pathology and that cutaneous proopiomelanocortin activity may be autoregulated by a feedback mechanism involving glucocorticoids synthesized locally by Slominski et al. Using in vitro studies, CYP11A1 catalyzed the side-chain cleavage of 7-dehydrocholesterol to form 7-dehydropregnenolone. In addition, it catalyzed the metabolism of biologically inert vitamin D3, which is formed from 7-dehydrocholesterol, to form 2 hydroxylated products, 20-hydroxyvitamin D3 and 20, 22-dihydroxyvitamin D3. Mutations in the gene cause congenital adrenal insufficiency with partial or complete 46, XY sex reversal.

UniProt: P05108

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin