CYP2E1 anticorps (N-Term)

N° du produit ABIN3030686

Détail du produit anti-CYP2E1 anticorps

Antigène: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Épitope: N-Term

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CYP2E1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the N-terminus of mouse CYP2E1 (KNEFSGRGDIPVFQEYKNK) was used as the immunogen for this Cytochrome P450 2E1 antibody (100% rat homology).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Cytochrome P450 2E1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Cytochrome P450 2E1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur CYP2E1

Antigène: CYP2E1 (Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 (CYP2E1))

Autre désignation: Cytochrome P450 2E1 (CYP2E1 Produits)

Synonymes: anticorps CYP2E1, anticorps CYP2E, anticorps CYPIIE1, anticorps CPE1, anticorps P450-J, anticorps P450C2E, anticorps Cyp2e, anticorps cytochrome P450, family 2, subfamily E, polypeptide 1, anticorps cytochrome P450 2E1, anticorps cytochrome P450 2E1-like, anticorps cytochrome P450 family 2 subfamily E member 1, anticorps cytochrome P450, family 2, subfamily e, polypeptide 1, anticorps CYP2E1, anticorps PTRG_07411, anticorps LOC100342572, anticorps LOC100727914, anticorps LOC101843716, anticorps Cyp2e1

Sujet: Cytochrome P450 2E1, also known as P450IIE1, is a member of the P450IIE subfamily which is ethanol-inducible. It has at least one gene which is mapped to 10q24.3-qter, and a second is likely in rat and in man. Both the rat and human proteins encoded by this gene contain 493 amino acids and calculated molecular masses of 56,634 and 56,916 daltons, respectively. In addition, genetic polymorphisms in the 5-prime flanking region of the human P450IIE1 gene affected its binding of transacting factor and changed its transcriptional regulation, which may lead to interindividual differences of microsomal drug oxidation activity. Cytochrome P450 2E1 is an important enzyme for the catalysis of the conversion of ethanol to acetaldehyde and to acetate in humans,and it is also involved in the metabolism of nitrosamines. Due to the possible correlation of P450IIE1 genes with malignancy, clinical studies of RFLP patterns of these genes in cancer may be useful.

UniProt: Q05421