DAXX anticorps (AA 325-341)

N° du produit ABIN3030705

Détail du produit anti-DAXX anticorps

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Épitope: AA 325-341

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DAXX est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: Amino acids 325-341 (QERRHLDLIYNFGCHLT) were used as the immunogen for this Daxx antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the Daxx antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the Daxx antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur DAXX

Antigène: DAXX (Death-Domain Associated Protein (DAXX))

Autre désignation: Daxx (DAXX Produits)

Synonymes: anticorps BING2, anticorps DAP6, anticorps EAP1, anticorps LOC100226911, anticorps daxx, anticorps si:dz179b20.7, anticorps wu:fd15c03, anticorps death domain associated protein, anticorps Fas death domain-associated protein, anticorps 28S ribosomal protein S29, mitochondrial, anticorps death-domain associated protein, anticorps death-associated protein 6 L homeolog, anticorps DAXX, anticorps Daxx, anticorps LOC100226911, anticorps daxx.L, anticorps daxx

Sujet: Death-domain associated protein, also known as DAP6 (Death-associated protein 6) or BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. The gene encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses byYang et al.(1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Western blot analysis with DAXX mutants showed that the N terminus of the protein interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway