E2F6 anticorps (Middle Region)

N° du produit ABIN3030791

Détail du produit anti-E2F6 anticorps

Antigène: E2F6 (E2F Transcription Factor 6 (E2F6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp E2F6 est non-conjugé

Application: Western Blotting (WB)

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human E2F6 (KDCAQQLFELTDDKEN) was used as the immunogen for this E2F6 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the E2F6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the E2F6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur E2F6

Antigène: E2F6 (E2F Transcription Factor 6 (E2F6))

Autre désignation: E2F6 (E2F6 Produits)

Synonymes: anticorps E2F-6, anticorps AI462434, anticorps E2F6b, anticorps EMA, anticorps E2F transcription factor 6, anticorps E2F6, anticorps E2f6

Sujet: E2F transcription factor 6 is also known as E2F-6. Northern blot analysis revealed that E2F6 is expressed as two mRNAs, 2.5 and 3.5 kb, in all human tissues and cell lines tested. The predicted human and mouse protein sequences are 92 % identical. The DNA-binding and dimerization domains of E2F6 are highly related to those of other E2F family members, but this protein lacks the sequences necessary for either transcriptional activation or binding to RB1, p107, or p130. E2F6 can act to repress the transcription of E2F-responsive genes by countering the activity of other E2F complexes. It contributes to gene silencing in a manner independent of retinoblastoma protein family members. It is found in a multimeric protein complex that contains MGA and MAX, and thus the complex can bind not only to the E2F binding site but also to MYC- and Brachyury- binding sites.The E2F6 complex preferentially occupies target promoters in G0 cells rather than in G1 cells.

UniProt: O75461