EIF6 anticorps (Middle Region)

N° du produit ABIN3030895

Détail du produit anti-EIF6 anticorps

Antigène: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Purification: Antigen affinity

Immunogène: An amino acid sequence from the middle region of human Eukaryotic Translation Initiation Factor 6 (QHIRNSLPDTVQIRR) was used as the immunogen for this EIF6 antibody.

Isotype: IgG

Information d'application

Indications d'application: The stated application concentrations are suggested starting amounts. Titration of the EIF6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IHC (Frozen): 0.5-1 μg/mL

Restrictions: For Research Use only

Stockage

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: -20 °C

Stockage commentaire: After reconstitution, the EIF6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Détails sur EIF6

Antigène: EIF6 (Eukaryotic Translation Initiation Factor 6 (EIF6))

Autre désignation: EIF6 (EIF6 Produits)

Synonymes: anticorps CAB, anticorps EIF3A, anticorps ITGB4BP, anticorps b(2)gcn, anticorps eIF-6, anticorps p27(BBP), anticorps p27BBP, anticorps 1110004P11, anticorps AA408895, anticorps Itgb4bp, anticorps imc-415, anticorps MGC56562, anticorps itgb4bp4, anticorps zgc:56562, anticorps wu:fc28a04, anticorps wu:ft88f05, anticorps itgb4bp, anticorps eukaryotic translation initiation factor 6, anticorps Eukaryotic translation initiation factor 6, anticorps eukaryotic translation initiation factor 6 S homeolog, anticorps translation initiation factor eIF6, anticorps EIF6, anticorps Eif6, anticorps eif6, anticorps eif-6, anticorps eif6.S, anticorps tif6

Sujet: EIF6 (Eukaryotic Translation Initiation Factor 6), also called ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al.(1998) mapped the gene to 20q11.2. Ceci et al.(2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, it is bound to free 60S but not to 80S subunits. Furthermore, the protein interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al.(2008) demonstrated that the protein is required for efficient initiation of translation in vivo. Null mouse embryos were lethal at preimplantation. Heterozygous mice had 50 % reduction of EIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression.

UniProt: P56537

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly