NLRP2 anticorps (C-Term)

N° du produit ABIN303221

L’anticorps anti-NLRP2 Polyclonal Lapin est utilisé pour la détection de NLRP2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC (p).

Aperçu rapide pour NLRP2 anticorps (C-Term) (ABIN303221)

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NLRP2 anticorps

Épitope: C-Term

Purification: IgG Fractionation.

Immunogène: Synthetic Peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot (1-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Détails sur NLRP2

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Autre désignation: NALP2

Sujet: NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli. Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1beta-processing activity and is thought to function as a modulator of NF-kappaB and procaspase-1 activation in macrophages. It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.Synonyms: LRR and PYD domains-containing protein 2, NACHT, NBS1, NLRP2, PAN1, PYPAF2

ID gène: 55655

NCBI Accession: NP_001167552

UniProt: Q9NX02

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome