IL1B anticorps (Interleukin 1, beta) (AA 249-263)

Details for Product anti-IL1B Antibody No. ABIN3043165
Antigène
  • il1-b
  • zgc:111873
  • IL-1beta
  • Il-1b
  • IL1B
  • IL-1
  • IL1-BETA
  • IL1F2
  • IL-1BETA
  • IL1beta
  • IL-1B
  • interleukin 1, beta
  • interleukin 1 beta
  • il1b
  • Il1b
  • IL1B
Épitope
AA 249-263, C-Term
27
24
16
15
15
15
12
12
11
10
8
8
7
6
6
5
5
5
5
4
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Rat (Rattus)
352
167
120
37
23
21
16
14
13
11
9
9
8
4
4
2
2
1
Hôte
Lapin
421
174
15
8
8
8
2
2
Clonalité
Polyclonal
Conjugué
Cet anticorp IL1B est non-conjugé
84
35
23
12
6
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
444
339
194
67
65
56
43
36
33
31
31
23
22
16
14
5
4
4
3
3
3
3
2
2
2
1
1
1
1
Options
Fonction Rabbit IgG polyclonal antibody for Interleukin-1 beta(IL1B) detection. Tested with WB, ELISA in Rat.
Immunogène A synthetic peptide corresponding to a sequence at the C-terminus of rat IL-1 beta(249-263aa FLGNSNGRDIVDFTM).
Séquence FLGNSNGRDI VDFTM
Isotype IgG
Réactivité croisée (Details) No cross reactivity with other proteins.
Attributs du produit Rabbit IgG polyclonal antibody for Interleukin-1 beta(IL1B) detection. Tested with WB, ELISA in Rat.
Gene Name: interleukin 1, beta
Protein Name: Interleukin-1 beta(IL-1 beta)
Purification Immunogen affinity purified.
Plasmids, Primers & others Plasmids, Primers & others IL1B products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation IL1B (IL1B Antibody Extrait)
Sujet Interleukin-1 beta(IL-1beta) also know as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene, which localizes to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites. Interleukin 1(IL-1) is a protein with several biological activities regulating host defense and immune responses. The human IL-1 family plays an important role in the pathogenesis of many diseases and functions as a key mediator of the host response to various infectious, inflammatory, and immunologic challenges.

Synonyms: Catabolin antibody|H1 antibody|Hematopoietin 1 antibody|IFN beta inducing factor antibody|IL 1 antibody|IL 1 beta antibody|IL 1B antibody|IL-1 beta antibody|IL1 BETA antibody|IL1B antibody|IL1B_HUMAN antibody|IL1F2 antibody|Interleukin 1 beta antibody|Interleukin 1 beta precursor antibody|Interleukin-1 beta antibody|LAF antibody|OAF antibody|Osteoclast activating factor antibody|OTTHUMP00000162031 antibody|Preinterleukin 1 beta antibody|Preinterleukin beta antibody|Pro interleukin 1 beta antibody
UniProt Q63264
Pathways Signalisation NF-kappaB, Interferon-gamma Pathway, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagy, Cancer Immune Checkpoints
Indications d'application WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat
ELISA: Concentration: 0.5-1 μg/mL, Tested Species: Rat

Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Commentaires

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
Concentration 500 μg/mL
Buffer Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
Agent conservateur Thimerosal (Merthiolate), Sodium azide
Précaution d'utilisation This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
Date de péremption 12 months
Images (Fournisseur)
Western Blotting (WB) image for anti-Interleukin 1, beta (IL1B) (AA 249-263), (C-Term) antibody (ABIN3043165) Anti- IL1beta antibody, Western blotting All lanes: Anti IL1beta at 0.5ug/ml Lane 1:...
Produit citée dans: Bi, Zeng, Zhao, Wei, Yu, Wang, Yu, Cao, Shan, Wei: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." dans: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, 2016 (PubMed).

Wang, Gong, Chen, Xiong, Zhou, Huang, Kong: "NLRP3 inflammasome sequential changes in Staphylococcus aureus-induced mouse model of acute rhinosinusitis." dans: International journal of molecular sciences, Vol. 15, Issue 9, pp. 15806-20, 2015 (PubMed).

Li, Chen, Zhang, Song, Mu: "Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model rats." dans: Neural regeneration research, Vol. 7, Issue 5, pp. 325-31, 2015 (PubMed).

Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." dans: PLoS ONE, Vol. 8, Issue 2, pp. e55839, 2013 (PubMed).

Yao, Peng, Peng, Tan, Wu, Wu, Chen, Li, Li, Zhu: "Effects of extract of Buddleja officinalis on partial inflammation of lacrimal gland in castrated rabbits with dry eye." dans: International journal of ophthalmology, Vol. 3, Issue 2, pp. 114-9, 2012 (PubMed).

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