PKC beta anticorps (AA 542-671)

N° du produit ABIN3043550

Détail du produit anti-PKC beta anticorps

Antigène: PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

Épitope: AA 542-671

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKC beta est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit IgG polyclonal antibody for Protein kinase C beta type(PRKCB) detection. Tested with WB in Human,Mouse,Rat.

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for Protein kinase C beta type(PRKCB) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: protein kinase C, beta
Protein Name: Protein kinase C beta type

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human PKC beta 1 recombinant protein (Position: E542-V671). Human PKC beta 1 shares 100% amino acid (aa) sequence identity with both mouse and rat PKC beta 1.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for PKC beta 1 is approximately 0.1 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Références pour anticorps anti-PKC beta (ABIN3043550)

Gan, Wang, Zhao, Wu, Yang, Peng: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." dans: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).

Wang, Qin, Deng, Yao: "Different localization and expression of protein kinase C-beta in kidney cortex of diabetic nephropathy mice and its role in telmisartan treatment." dans: American journal of translational research, Vol. 7, Issue 6, pp. 1116-25, (2015) (PubMed).

Détails sur PKC beta

Antigène: PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

Autre désignation: PRKCB (PRKCB Produits)

Synonymes: anticorps PKC-beta, anticorps PKCB, anticorps PRKCB1, anticorps PRKCB2, anticorps A130082F03Rik, anticorps PKC-Beta, anticorps Pkcb, anticorps Prkcb1, anticorps Prkcb2, anticorps PKC-B, anticorps Prkcb, anticorps prkcb1, anticorps zgc:63591, anticorps PKC, anticorps PRKCB_tv2, anticorps Pkc53E, anticorps prkcb1l, anticorps zgc:64063, anticorps protein kinase C beta, anticorps protein kinase C, beta, anticorps protein kinase C, beta b, anticorps protein kinase C, beta a, anticorps PRKCB, anticorps Prkcb, anticorps prkcbb, anticorps prkcba

Sujet: Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene. It is a member of the protein kinase C (PKC) gene family. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. It has been found that PRKCB activated by oxidative conditions in the cell, induces phosphorylation of p66(SHC) and triggers mitochondrial accumulation of the protein after it is recognized by the prolyl isomerase PIN1.

Synonyms: KPCB_HUMAN antibody|MGC41878 antibody|PKC B antibody|PKC beta antibody|PKC-B antibody|PKC-beta antibody|PKCB antibody|PRKC B antibody|PRKC B1 antibody|PRKCB antibody|PRKCB I antibody|PRKCB1 antibody|PRKCB2 antibody|Protein kinase C beta 1 antibody|Protein kinase C beta antibody|Protein kinase C beta type antibody|protein kinase C, beta 1 polypeptide antibody|protein kinase C, beta-1 antibody

ID gène: 5579

UniProt: P05771

Pathways: Signalisation WNT, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling