MCM6 anticorps (Middle Region)

N° du produit ABIN3044159

Détail du produit anti-MCM6 anticorps

Antigène: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Épitope: AA 589-605, Middle Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCM6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Fonction: Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM6(MCM6) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.

Séquence: ESEDFIVEQY KHLRQRD

Réactivité croisée (Details): No cross reactivity with other proteins.

Attributs du produit: Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM6(MCM6) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: minichromosome maintenance complex component 6
Protein Name: DNA replication licensing factor MCM6

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of human MCM6(589-605aa ESEDFIVEQYKHLRQRD), different from the related rat and mouse sequences by one amino acid.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MCM6

Antigène: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Autre désignation: MCM6 (MCM6 Produits)

Synonymes: anticorps CG4039, anticorps DmMCM6, anticorps DmeMCM6, anticorps Dmel\\CG4039, anticorps MCM6, anticorps McM6, anticorps fs(1)K1214, anticorps mcm6, anticorps MCG40308, anticorps Mis5, anticorps P105MCM, anticorps Mcmd6, anticorps mis5, anticorps mmcm6, anticorps ASP-l1, anticorps D1Wsu22e, anticorps Minichromosome maintenance 6, anticorps DNA replication licensing factor MCM6, anticorps minichromosome maintenance complex component 6, anticorps minichromosome maintenance complex component 6 L homeolog, anticorps DNA replication licensing factor mcm-6, anticorps Mcm6, anticorps TP02_0113, anticorps PVX_114735, anticorps CMU_027970, anticorps MCM6, anticorps mcm6.L, anticorps mcm-6

Sujet: MCM6(Minichromosome maintenance, s. pombe, homolog of, 6) is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins(MCM) that are essential for the initiation of eukaryotic genome replication. The MCM genes were originally identified in yeast defective in minichromosome maintenance and have since been shown to play roles in the progression of the cell cycle, many are cell division control genes. The MCM6 gene is mapped on 2q21.3. Mcm 6 has recently been shown to interact strongly Cdt1 at defined residues, by mutating these target residues Wei et al. observed lack of Cdt1 recruitment of Mcm2-7 to the pre-RC. An approximately 200-kb region surrounding the C/T(-13910) polymorphism in MCM6 intron 13 functioned as an enhancer of the lactase gene promoter in intestinal cell culture.

Synonyms: DNA replication licensing factor MCM6 antibody|MCG40308 antibody|Mcm6 antibody|MCM6 minichromosome maintenance deficient 6(MIS5 homolog, S. pombe) antibody|MCM6 minichromosome maintenance deficient 6 antibody|MCM6_HUMAN antibody|Minichromosome maintenance complex component 6 antibody|Minichromosome maintenance deficient(mis5 S. pombe) 6 antibody|Minichromosome maintenance deficient 6 homolog antibody|Minichromosome maintenance protein 6 antibody|Mis5 antibody|MIS5 homolog antibody|p105MCM antibody

UniProt: Q14566

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA