FOXP1 anticorps (C-Term)

N° du produit ABIN3044456

Détail du produit anti-FOXP1 anticorps

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Épitope: AA 657-677, C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: Rabbit IgG polyclonal antibody for Forkhead box protein P1(FOXP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Séquence: HSPDFDHDRD YEDEPVNEDM E

Réactivité croisée (Details): Predicted Cross Reactivity: mouse
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Attributs du produit: Rabbit IgG polyclonal antibody for Forkhead box protein P1(FOXP1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: forkhead box P1
Protein Name: Forkhead box protein P1

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1(657-677aa HSPDFDHDRDYEDEPVNEDME),identical to the related rat and mouse sequences.

Isotype: IgG

Information d'application

Indications d'application: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

Commentaires:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Agent conservateur: Thimerosal (Merthiolate), Sodium azide

Précaution d'utilisation: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur FOXP1

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Autre désignation: FOXP1 (FOXP1 Produits)

Synonymes: anticorps 12CC4, anticorps QRF1, anticorps hFKH1B, anticorps 3110052D19Rik, anticorps 4932443N09Rik, anticorps AI461938, anticorps AW494214, anticorps foxp1, anticorps im:7139058, anticorps wu:fc83a06, anticorps FOXP1, anticorps MGC145686, anticorps 12cc4, anticorps fkh1b, anticorps hspc215, anticorps qrf1, anticorps xlfoxp1, anticorps im:7146611, anticorps wu:fb97f01, anticorps zgc:154010, anticorps forkhead box P1, anticorps forkhead box P1b, anticorps forkhead box P1 S homeolog, anticorps forkhead box P1a, anticorps FOXP1, anticorps Foxp1, anticorps foxp1b, anticorps foxp1, anticorps foxp1.S, anticorps foxp1a

Sujet: FOXP1("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

Synonyms: 12CC4 antibody|FLJ23741 antibody|Fork head related protein like B antibody|Forkhead box P1 antibody|Forkhead box protein P1 antibody|FOX P1 antibody|FOXP 1 antibody|foxp1 antibody|FOXP1_HUMAN antibody|Glutamine rich factor 1 antibody|hFKH1B antibody|HSPC215 antibody|MGC12942 antibody|MGC88572 antibody|MGC99551 antibody|QRF 1 antibody|QRF1 antibody

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response