SPARC anticorps

N° du produit ABIN307028

Détail du produit anti-SPARC anticorps

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPARC est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Attributs du produit: Secreted Protein Acidic and Rich in Cysteine, SPARC, SPARC-related modular calcium-binding protein 2 [Precursor], Secreted modular calcium-binding protein 2, SMOC-2, Smooth muscle-associated protein 2, SMAP-2,SPARC is a key factor in cell-matrix interactions and possibly tumour aggressiveness. The SPARC gene, which encodes a multifunctional glycoprotein with roles in tissue development, remodelling and fibrosis. A regulator of cell-extracellular matrix (ECM) interactions, SPARC represents a major factor in the ECM remodelling occurring during tumour invasion. in silico analysis reveals 4 UTR-SNPs located in the 3 -UTR of the SPARC gene, corresponding to 1474 g a, 1551 g c, 1922 t g and 2072 c t changes, which are significantly associated with tumoral state of the tissue. Of all hits, the 2072 SPARC polymorphism had the best association with cancer. SPARC therefore is a gene involved in a number of diseases including rheumatoid arthritis, scleroderma, tumor development and metastasis. SPARC variants have been detected in tumour samples of patients with acute myeloblastic leukemia (AML).

Purification: Ammonium Sulfate Precipitation

Immunogène: Rabbit immunized with a synthetic peptide derived from the human SPARC protein.

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (1-5 μg/mL), Immunohistochemistry and ELISA. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur SPARC

Antigène: SPARC (Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC))

Autre désignation: SPARC (SPARC Produits)

Synonymes: anticorps ON, anticorps AA517111, anticorps BM-40, anticorps hm:zeh0062, anticorps SPARC, anticorps sparc, anticorps secreted protein acidic and cysteine rich, anticorps secreted acidic cysteine rich glycoprotein, anticorps secreted protein, acidic, cysteine-rich (osteonectin), anticorps secreted protein, acidic, cysteine-rich (osteonectin) L homeolog, anticorps secreted protein, acidic, cysteine-rich (osteonectin) S homeolog, anticorps SPARC, anticorps Sparc, anticorps sparc, anticorps sparc.L, anticorps sparc.S

UniProt: P09486

Pathways: Autophagy