Prothrombin anticorps

N° du produit ABIN317606

Détail du produit anti-Prothrombin anticorps

Antigène: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prothrombin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Prothrombin protein.(region surrounding Gly724)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: Western Blot: 1/500-1/1000. ELISA: 1/10000-1/20000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Prothrombin

Antigène: Prothrombin (F2) (Coagulation Factor II (thrombin) (F2))

Autre désignation: Prothrombin (F2) (F2 Produits)

Synonymes: anticorps PT, anticorps RPRGL2, anticorps THPH1, anticorps Cf-2, anticorps Cf2, anticorps FII, anticorps thrombin, anticorps zgc:66319, anticorps wu:fb57c10, anticorps wu:fd42e09, anticorps wu:fd59d01, anticorps prothrombin, anticorps F2, anticorps coagulation factor II, thrombin, anticorps coagulation factor II, anticorps coagulation factor II (thrombin), anticorps F2, anticorps f2

Sujet: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (Prothrombin and Factors X, IX, V and VIII), which mediate a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Proteolytic cleavage of Prothrombin (Factor II) at residue 44 leads to formation of Thrombin in the first step of the coagulation cascade. Thrombin cleaves bonds between Arg and Gly and activates Factors V, VII, VIII and XIII in complex with thrombomodulin and Protein C. Thrombin maintains vascular integrity during development and postnatal life and coordinates connective tissue proteins by stimulating fibroblast procollagen production.Synonyms: Coagulation factor II

Poids moléculaire: approx. 70 kDa

ID gène: 2147

NCBI Accession: NP_000497

UniProt: P00734

Pathways: Système du Complément, Peptide Hormone Metabolism, Regulation of G-Protein Coupled Receptor Protein Signaling