ELISA: 1/10000-1/20000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
anticorps DT1P1B11, anticorps PHRIP, anticorps TDAG51, anticorps Tdag, anticorps pleckstrin homology like domain family A member 1, anticorps pleckstrin homology like domain, family A, member 1, anticorps pleckstrin homology-like domain, family A, member 1, anticorps pleckstrin homology-like domain, family A, member 1 L homeolog, anticorps PHLDA1, anticorps Phlda1, anticorps phlda1.L
Sujet
Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immunosurveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a 48 kDa cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation- induced apoptosis in cells that have lost the ability to display Fas in response to activation. Thus, TDAG51 plays a critical role in T cell apoptosis by coupling TCR.Synonyms: Apoptosis-associated nuclear protein, PHRIP, PQ-rich protein, PQR protein, Pleckstrin homology-like domain family A member 1, Proline- and glutamine-rich protein, Proline- and histidine-rich protein, T-cell death-associated gene 51 protein