CLCN6 anticorps

N° du produit ABIN317827

Détail du produit anti-CLCN6 anticorps

Antigène: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLCN6 est non-conjugé

Application: Western Blotting (WB)

Specificité: CLC-6 antibody detects endogenous levels of CLC-6 protein.(region surrounding Lys649)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CLCN6

Antigène: CLCN6 (Chloride Channel, Voltage-Sensitive 6 (CLCN6))

Autre désignation: CLCN6 (CLCN6 Produits)

Synonymes: anticorps CLC-6, anticorps AI850629, anticorps CLCN6, anticorps wu:fb95f01, anticorps DKFZp469B244, anticorps DKFZp469L0417, anticorps chloride voltage-gated channel 6, anticorps chloride channel, voltage-sensitive 6, anticorps chloride channel 6, anticorps chloride transport protein 6, anticorps CLCN6, anticorps Clcn6, anticorps clcn6, anticorps LOC579870

Sujet: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume. The genes encoding human CLC-1 through CLC-7 map to chromosomes 7, 3q26, 4q32, Xp22, Xp11, 1p36 and 16p13, respectively. CLC-1 is highly expressed in skeletal muscle. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be a possible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle.Synonyms: Chloride channel protein 6, Chloride transport protein 6, ClC-6, ClC6, KIAA0046

Poids moléculaire: approx. 90 kDa

ID gène: 1185

NCBI Accession: NP_001277

UniProt: P51797