PTGER3 anticorps

N° du produit ABIN317859

Détail du produit anti-PTGER3 anticorps

Antigène: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PTGER3 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of EP3 protein.(region surrounding Arg39)

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur PTGER3

Antigène: PTGER3 (Prostaglandin E Receptor 3 (Subtype EP3) (PTGER3))

Autre désignation: PTGER3 (PTGER3 Produits)

Synonymes: anticorps PTGER3, anticorps EP3, anticorps EP3-I, anticorps EP3-II, anticorps EP3-III, anticorps EP3-IV, anticorps EP3e, anticorps PGE2-R, anticorps PTGEREP3, anticorps Rep3, anticorps rEP3a, anticorps rEP3b, anticorps Pgerep3, anticorps Ptgerep3, anticorps prostaglandin E receptor 3, anticorps prostaglandin E receptor 3 L homeolog, anticorps prostaglandin E receptor 3 (subtype EP3), anticorps PTGER3, anticorps ptger3.L, anticorps Ptger3

Sujet: Prostaglandin E2, a member of the autacoid family of lipid mediators, is a major renal cyclooxygenase product of arachidonic acid metabolism. Prostaglandin E2 binds to four G protein-coupled E-prostanoid receptors, designated EP1, EP2, EP3 and EP4. The expression and function of the prostaglandin E2 receptors have been highly characterized in kidney. EP1, which is predominantly expressed in the collecting duct, couples to Gq proteins to inhibit sodium absorption and increase in intracellular calcium, which act as second messengers. EP2 is coupled to Gs proteins, which stimulate adenylyl cyclase. EP2 has the lowest expression in kidney, but EP2 knockout mice exhibit saltsensitive hypertension, which suggests a role for EP2 in salt excretion. EP3, which is expressed in renal vessels, thick ascending limb and collecting duct, has at least six alternative splice variants that couple to Gi proteins to inhibit cAMP, which subsequently inhibit sodium and water transport. In uterus, EP3 induces the contraction of uterine smooth muscles. EP4 is expressed in glomerulus and collecting duct.Synonyms: EP3, EP3-II, EP3-III, PGE receptor EP3 subtype, PGE2 receptor EP3 subtype, PGE2-R, Prostaglandin E receptor 3, Prostaglandin E2 receptor EP3 subtype, Prostanoid EP3 receptor

Poids moléculaire: approx. 40 kDa

ID gène: 5733

NCBI Accession: NP_001119516

UniProt: P43115