Prostacyclin Receptor anticorps

N° du produit ABIN317863

Détail du produit anti-Prostacyclin Receptor anticorps

Antigène: Prostacyclin Receptor (PTGIR)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Prostacyclin Receptor est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: IP Receptor antibody detects endogenous levels of IP Receptor protein.(region surrounding His237)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur Prostacyclin Receptor

Antigène: Prostacyclin Receptor (PTGIR)

Autre désignation: Prostacyclin Receptor / PTGIR (PTGIR Produits)

Synonymes: anticorps IP, anticorps PGI2, anticorps PRIPR, anticorps prostaglandin I receptor (IP), anticorps prostaglandin I2 receptor, anticorps Ptgir, anticorps PTGIR

Sujet: Cyclooxygenases metabolize arachidonate to five primary prostanoids: PGE2, PGF2α, PGI2, TXA2 and PGD2. These lipid mediators interact with specific members of G protein-coupled prostanoid receptors, designated EP, FP, IP, TP and DP, respectively. The IP Receptor binds prostacyclin, PGI2, the main prostanoid synthesized by vascular tissues. First discovered in 1976, prostacyclin is involved in platelet aggregation inhibition, vasodilatation and cytoprotection, and either prostacyclin or its analogs are used in the treatment of hypertension. Upon binding to the IP Receptor, prostacyclin activates adenylate cyclase primarily through the Gas protein. The gene encoding the human IP Receptor is located on chromosome 19. It is expressed as a glycosylated and phosphorylated protein, which is abundantly expressed in vascular tissues such as aorta, lung, atrium and ventricle, as well as in kidney, thymus, spleen and neurons.Synonyms: PGI receptor, PRIPR, Prostaglandin I2 receptor, Prostanoid IP receptor

Poids moléculaire: approx. 45 kDa

ID gène: 5739

NCBI Accession: NP_000951

UniProt: P43119

Pathways: cAMP Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling