GNL1 anticorps
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- Antigène Voir toutes GNL1 Anticorps
- GNL1 (Guanine Nucleotide Binding Protein Like Protein 1 (GNL1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp GNL1 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- GNL1 antibody detects endogenous levels of GNL1 protein.(region surrounding Gln103)
- Purification
- Affinity chromatography
- Top Product
- Discover our top product GNL1 Anticorps primaire
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- Indications d'application
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Antigène
- GNL1 (Guanine Nucleotide Binding Protein Like Protein 1 (GNL1))
- Autre désignation
- GNL1 / HSR1 (GNL1 Produits)
- Synonymes
- anticorps HSR1, anticorps Gna-rs1, anticorps Gnal1, anticorps G protein nucleolar 1 (putative), anticorps guanine nucleotide binding protein-like 1, anticorps G protein nucleolar 1, anticorps GNL1, anticorps Gnl1
- Sujet
- GNL1 (guanine nucleotide-binding protein-like 1) is a nuclear protein that likely acts as a regulator of the histocompatibility cluster. GNL1 and MMR1, the murine homolog, are localized within or close to the MHC class I region and belong to the MMR1/HSR1 GTP-binding protein family. GTPases, such as GNL1, from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein RPL25A to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. Upon DNA damage GNL1 is phosphorylated by a kinase, possibly Atm or ATR.Synonyms: GTP-binding protein HSR1, Guanine nucleotide-binding protein-like 1
- Poids moléculaire
- approx. 69 kDa
- ID gène
- 2794
- NCBI Accession
- NP_005266
- UniProt
- P36915
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