DCT anticorps

N° du produit ABIN317917

Détail du produit anti-DCT anticorps

Antigène: DCT (Dopachrome Tautomerase (DCT))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCT est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: TRP2 antibody detects endogenous levels of TRP2 protein.(region surrounding Lys89)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur DCT

Antigène: DCT (Dopachrome Tautomerase (DCT))

Autre désignation: TYRP2 / DCT (DCT Produits)

Synonymes: anticorps TYRP2, anticorps RGD1564975, anticorps trp2, anticorps DT, anticorps TRP-2, anticorps TRP2, anticorps Tyrp-2, anticorps Tyrp2, anticorps slaty, anticorps slt, anticorps zgc:109860, anticorps dopachrome tautomerase, anticorps dopachrome tautomerase L homeolog, anticorps DCT, anticorps Dct, anticorps dct, anticorps dct.L

Sujet: Tyrosinase (TYR), a type I membrane protein and copper-containing enzyme,is involved in the production of melanin, the primary pigment found in vertebrates.Melanin biogenesis requires the enzymatic activity of TYR, which catalyzes the critical and rate-limiting step of tyrosine hydroxylation in the biosynthesis of melanin. Defects effecting TYR activity result in various forms of albinism. The TYR-related proteins, TRP1 and TRP2, are also specifically expressed in melanocytes, and they likewise contribute to the synthesis of melanin within the melanosomes. The TRPs, including TYR, all share a similar transmembrane region, contain two metal-binding regions and a cysteinerich epidermal growth factor motif, and are localized in the melanosomal membrane. These proteins, however, have distinct catalytic activity, and they individually contribute to the biosynthesis of melanin biopolymers. The TRPs are believed to exist as a multi-enzyme complex, as these proteins form aggregates together, and the expression of TRP1 also helps stabilize TYR in melanocytes.Synonyms: L-dopachrome Delta-isomerase, L-dopachrome tautomerase, TRP-2, TRP2, Tyrosinase-related protein 2

Poids moléculaire: approx. 60 kDa

ID gène: 1638

NCBI Accession: NP_001913

UniProt: P40126