SPTBN1 anticorps

N° du produit ABIN317939

Détail du produit anti-SPTBN1 anticorps

Antigène: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPTBN1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Spectrin β II antibody detects endogenous levels of Spectrin β II protein.(region surrounding Met687)

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SPTBN1

Antigène: SPTBN1 (Spectrin Beta, Non-Erythrocytic 1 (SPTBN1))

Abstract: SPTBN1 Produits

Synonymes: anticorps 9930031C03Rik, anticorps AL033301, anticorps SPTB2, anticorps Spnb-2, anticorps Spnb2, anticorps elf1, anticorps elf3, anticorps mKIAA4049, anticorps ELF, anticorps betaSpII, anticorps Spnb1, anticorps spectrin beta, non-erythrocytic 1, anticorps spectrin, beta, non-erythrocytic 1, anticorps Sptbn1, anticorps SPTBN1

Sujet: Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin α I and spectrin β I are present in erythrocytes, whereas spectrin α II (also designated fodrin α) and spectrin β II (also designated fodrin β) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin β I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of β-spectrin.Synonyms: Beta-II spectrin, Fodrin beta chain, SPTB2, Spectrin beta chain brain 1, Spectrin non-erythroid beta chain 1

Poids moléculaire: approx. 275 kDa

ID gène: 6711

NCBI Accession: NP_003119

UniProt: Q01082

Pathways: Regulation of Actin Filament Polymerization, Protein targeting to Nucleus