CDC25C anticorps (pSer216)

N° du produit ABIN317983

Cet anticorps Lapin Polyclonal détecte spécifiquement CDC25C dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CDC25C anticorps (pSer216) (ABIN317983)

Antigène: CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC25C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-CDC25C anticorps

Épitope: pSer216

Specificité: P-CDC25C (pSer216) antibody detects endogenous levels of p-CDC25C protein.

Purification: Affinity chromatography

Information d'application

Indications d'application: ELISA: 1: 10000approx. 1: 20000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur CDC25C

Antigène: CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))

Autre désignation: CDC25C

Sujet: Cell cycle events are regulated by the sequential activation and deactivation of cyclin-dependent kinases (Cdks), including Cdk2 and Cdc2. Cdk2, in complexes with cyclin E and cyclin A, appears necessary for the onset and progression of DNA replication, while the Cdc2 kinase, in complexes with cyclin A or cyclin B, is required for the initiation of cell division. Wee 1 has been identified as a protein kinase that suppresses the entry into mitosis by mediating inhibiting tyrosine phosphorylation of Cdc2 p34. In contrast, members of the Cdc25 family of protein phosphatases function as mitotic activators by dephosphorylation of Cdc2 p34 on regulatory tyrosine and possibly threonine residues. The Cdc25 gene family consists of at least three members that share approximately 40 % identity in their most conserved carboxy-terminal sequences.Synonyms: Cell Division Cycle 25C, Dual specificity phosphatase Cdc25C, M-phase inducer phosphatase 3

Poids moléculaire: approx. 53 kDa

ID gène: 995

NCBI Accession: NP_001781

UniProt: P30307

Pathways: Cycle Cellulaire, M Phase