FGFR1 anticorps (AA 152-156)

N° du produit ABIN319331

L’anticorps anti-FGFR1 Polyclonal Lapin est utilisé pour la détection de FGFR1 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB.

Aperçu rapide pour FGFR1 anticorps (AA 152-156) (ABIN319331)

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FGFR1 anticorps

Épitope: AA 152-156

Specificité: This antibody detects endogenous levels of total FGF Receptor 1 (CD331/FGFR1) protein.

Purification: Immunoaffinity Chromatography using epitope-specific peptide

Immunogène: Peptide sequence around amino acids 152-156 (A-P-Y-W-T) derived from FGF Receptor 1 Human.

Information d'application

Indications d'application: Western Blot (1/500-1/1000). Incubate membrane with diluted antibody in 5 % nonfat milk, 1X TBSS, 0.1 % Tween-20 at4 °C with gentle shaking, overnight.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C.

Détails sur FGFR1

Antigène: FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))

Autre désignation: FGFR1

Sujet: FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates. It may be found in most anchorage dependent cells on their membrane and also may be localized around and in nuclei. Pfeiffer syndrome, as well as other disorders of human skeletal development, is the result of a mutation in the extracellular domain of FGFR1.Synonyms: BFGFR, Basic fibroblast growth factor receptor 1, CEK, FGFBR, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, N-sam, Proto-oncogene c-Fgr, bFGF-R-1

Poids moléculaire: 145 kDa

ID gène: 2260

NCBI Accession: NP_001167534

UniProt: P11362

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins