ATR anticorps (Ser428)

N° du produit ABIN319379

L’anticorps Lapin Polyclonal anti-ATR a été validé pour IHC (p). Il convient pour détecter ATR dans des échantillons de Humain.

Aperçu rapide pour ATR anticorps (Ser428) (ABIN319379)

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATR est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATR anticorps

Épitope: Ser428

Specificité: This antibody detects endogenous levels of total ATR protein.

Purification: Immunoaffinity Chromatography.

Immunogène: The antiserum was produced against synthesized non-phosphopeptide derived from human ATR around the phosphorylation site of Serine 428 (G-I-SP-P-K).

Information d'application

Indications d'application: Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at-20 °C.

Détails sur ATR

Antigène: ATR (Ataxia Telangiectasia and Rad3 Related (ATR))

Autre désignation: ATR / FRP1

Sujet: Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR

ID gène: 545

NCBI Accession: NP_001175

UniProt: Q13535

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Positive Regulation of Response to DNA Damage Stimulus