Integrin Alpha2b anticorps

N° du produit ABIN320116

Cet anticorps Rat Monoclonal détecte spécifiquement Integrin Alpha2b dans FACS, IP et IHC (fro). Il présente une réactivité envers Souris et a été mentionné dans 6+ publications.

Aperçu rapide pour Integrin Alpha2b anticorps (ABIN320116)

Antigène: Integrin Alpha2b (CD41)

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin Alpha2b est non-conjugé

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: MWReg30

Détail du produit anti-Integrin Alpha2b anticorps

Specificité: This antibody recognizes the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo (Nieswandt et al., 1999). SM2035A is recommended for use in functional studies.

Purification: Affinity Chromatography on Protein G.

Isotype: IgG1

Information d'application

Indications d'application: Flow Cytometry (1/50-1/100): Use 10 μL to label 10^6 cells in 100 μL. Immunohistology on Frozen Sections. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS, containing 0.09 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Références pour anticorps anti-Integrin Alpha2b (ABIN320116)

Koski, Bramante, Kipar, Oksanen, Juhila, Vassilev, Joensuu, Kanerva, Hemminki: "Biodistribution Analysis of Oncolytic Adenoviruses in Patient Autopsy Samples Reveals Vascular Transduction of Noninjected Tumors and Tissues." dans: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 23, Issue 10, pp. 1641-52, (2016) (PubMed).

Pennings, Siljee, Imholz, Kuc, de Vries, Schielen, Rodenburg: "Comparison of different blood collection, sample matrix, and immunoassay methods in a prenatal screening setting." dans: Disease markers, Vol. 2014, pp. 509821, (2015) (PubMed).

Teeling, Carare, Glennie, Perry: "Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction." dans: Acta neuropathologica, Vol. 124, Issue 4, pp. 479-90, (2012) (PubMed).

Haglund, Tillgren, Addis, Wenglén, Recklies, Heinegård: "Identification and characterization of the integrin alpha2beta1 binding motif in chondroadherin mediating cell attachment." dans: The Journal of biological chemistry, Vol. 286, Issue 5, pp. 3925-34, (2011) (PubMed).

Sullivan, Wang, Tawfik, Luyendyk: "Protective and damaging effects of platelets in acute cholestatic liver injury revealed by depletion and inhibition strategies." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 115, Issue 1, pp. 286-94, (2010) (PubMed).

Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: "Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts." dans: Immunology and cell biology, Vol. 74, Issue 6, pp. 490-6, (1997) (PubMed).

Détails sur Integrin Alpha2b

Antigène: Integrin Alpha2b (CD41)

Autre désignation: CD41 / ITGA2B

Sujet: CD41, a ~125 kDa single pass type 1 transmembrane glycoprotein, is expressed on platelets, megakaryocytes, mast cells and hematopoietic progenitors and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

ID gène: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex