TRPV5 anticorps (4th Cytoplasmic Loop)

N° du produit ABIN351299

Détail du produit anti-TRPV5 anticorps

Antigène: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Épitope: 4th Cytoplasmic Loop

Reactivité: Lapin

Hôte: Mouton

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPV5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: Specific for TRPV5.

Immunogène: A synthetic peptide from the 4th cytoplasmic loop of rabbit TRPV5 conjugated to an immunogenic carrier protein was used as the immunogen.

Isotype: IgG

Information d'application

Indications d'application: A concentration of 10-50 µg/ml is recommended.
The optimal dilution should be determined by the end user.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Conseil sur la manipulation: Avoid freeze and thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Date de péremption: 12 months

Détails sur TRPV5

Antigène: TRPV5 (Transient Receptor Potential Cation Channel, Subfamily V, Member 5 (TRPV5))

Autre désignation: TRPV5 (TRPV5 Produits)

Synonymes: anticorps CaT2, anticorps Ecac1, anticorps CAT2, anticorps ECAC1, anticorps OTRPC3, anticorps D630033B11, anticorps TRPV5, anticorps ECAC, anticorps cat2, anticorps xcat2, anticorps transient receptor potential cation channel, subfamily V, member 5, anticorps transient receptor potential cation channel subfamily V member 5, anticorps calcium transporter 2 L homeolog, anticorps Trpv5, anticorps TRPV5, anticorps LOC100011049, anticorps trpv5, anticorps cat2.L

Sujet: This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
Function: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
Subcellular location: Apical cell membrane, Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
Tissue specificity: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. Also known as: TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5.