Ubiquitin anticorps

N° du produit ABIN356467

Détail du produit anti-Ubiquitin anticorps

Antigène: Ubiquitin

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ubiquitin est non-conjugé

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificité: This antibody stains senile plaques and neurons.
Cellular Localization: Nuclear, Cytoplasmic, and cell membrane.

Purification: Protein A Chromatography

Immunogène: Purified Human Ubiquitin.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/100 usingstreptavidinapprox. biotin system or polymer system. FFPE tissue sections require antigenretriever, boiling tissue for 15-20 minutes in 10 mM citrate, pH 6.0, followed by cooling atRT for 15-20 minutes. Immunofluorescence. Recommended Positive Control: Human brain from Alzheimer's disease.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 3 mg/mL

Buffer: PBS, pH 7.4 containing 1 % BSA as stabilizer and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur Ubiquitin

Antigène: Ubiquitin

Autre désignation: Ubiquitin (Ubiquitin Produits)

Synonymes: anticorps CG11624, anticorps DmUb, anticorps DmUbi-p63E, anticorps Dmel\\CG11624, anticorps Ub, anticorps Ubi-P63e, anticorps Ubi-p, anticorps Ubi63E, anticorps Ubi63p, anticorps Ubip, anticorps Ubiq, anticorps Ubp, anticorps ubi, anticorps ubi-p63E, anticorps ubi63E, anticorps CG18282, anticorps CG32744, anticorps CR32744, anticorps DmUbi-p5E, anticorps Dmel\\CG32744, anticorps ubiquitin, anticorps si:dz180g5.5, anticorps si:busm1-180g5.5, anticorps LOC100194618, anticorps UBIQ, anticorps Ubiquitin, anticorps LOC100282068, anticorps Ubiquitin-63E, anticorps Ubiquitin-5E, anticorps transmembrane and ubiquitin-like domain containing 2, anticorps polyubiquitin, anticorps Putative ubiquitin family protein, anticorps ubiquitin, anticorps ubiquitin B, anticorps UBiQuitin, anticorps Ubiquitin, anticorps Ubi-p63E, anticorps Ubi-p5E, anticorps tmub2, anticorps LOC100194618, anticorps pco110026, anticorps LOC100135798, anticorps UBB, anticorps ubq-1, anticorps LOC100190766

Sujet: Ubiquitin is a 76 amino acids 8.5 kDa, a highly conserved small regulatory protein that is ubiquitously expressed in eukaryotes and plays a central role in protein degradation. The Ubiquitin/proteosome pathways are main, non-lysomal route for intracellular protein degradation. The protein to be degraded is conjugated to Ubiquitin, it is selectively degraded by 26S complex multicatalytic cytosolic and nuclear protease termed proteosome. This protein also plays important role in cellular processes e.g. Cell cycle progression, gene transcription, antigen processing and signal transduction. In Immunohistochemistry (IHC) this antibody can detect abnormal inclusion bodies, in neurofibrillary tangles in Alzheimer's disease, lewy bodies in Parkinson's disease, pick bodies in Pick's disease, inclusions in motor neuron disease, Mallory's Haylin in alcoholic liver disease and Rosenthal fibers in astrocytes.Synonyms: Polyubiquitin-B, UBB

ID gène: 7314

UniProt: P0CG47

Pathways: Mitotic G1-G1/S Phases, Ubiquitin Proteasome Pathway