NBL1 anticorps

N° du produit ABIN360878

Détail du produit anti-NBL1 anticorps

Antigène: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Reactivité: Souris

Hôte: Rat

Clonalité: Monoclonal

Conjugué: Cet anticorp NBL1 est non-conjugé

Application: Western Blotting (WB)

Specificité: This antibody detects Mouse DAN in Western blotting.

Purification: Protein A/G affinity chromatography

Immunogène: Recombinant DAN

Clone: 7K12

Isotype: IgG2

Information d'application

Indications d'application: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Reconstitution: Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: 0.2 μm filtered PBS, None

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur NBL1

Antigène: NBL1 (Neuroblastoma 1, DAN Family BMP Antagonist (NBL1))

Autre désignation: NBL1 (NBL1 Produits)

Synonymes: anticorps D1S1733E, anticorps DAN, anticorps DAND1, anticorps NB, anticorps NO3, anticorps D4H1S1733E, anticorps Dana, anticorps dand1, anticorps nbl1-a, anticorps no3, anticorps 4.1N, anticorps Epb41l1, anticorps NBL1, anticorps mKIAA0338, anticorps C1orf151-NBL1, anticorps dan, anticorps zgc:77251, anticorps neuroblastoma 1, DAN family BMP antagonist, anticorps neuroblastoma, suppression of tumorigenicity 1, anticorps neuroblastoma 1, DAN family BMP antagonist L homeolog, anticorps neuroblastoma suppressor of tumorigenicity 1, anticorps erythrocyte membrane protein band 4.1 like 1, anticorps MINOS1-NBL1 readthrough, anticorps NBL1, anticorps Nbl1, anticorps nbl1.L, anticorps LOC535280, anticorps Epb41l1, anticorps MINOS1-NBL1, anticorps nbl1

Sujet: DAN (differential screening-selected gene aberrative in neuroblastoma) was initially identified as a gene whose expression is downregulated in srctransformed rat fibroblasts. DAN has now been shown to be a prototypical member of the DAN family of secreted glycoproteins that are putative BMP antagonists. DAN family members share a cysteinerich domain that is structurally related to the cysteineknot motif found in TGFβ superfamily ligands. There are at least five mouse DAN family members, including DAN, Gremlin/DRM, Cer1 (Cerberusrelated), Dante and PRDC (protein-related to DAN and cerberus). Additional DAN family members include Xenopus Cerberus, chick Caronte, and C. elegans CeCan 1. Murine DAN binds BMP2 in immunoprecipitation experiments and acts as a BMP antagonist in Xenopus animal cap explants. The DAN family of proteins are thought to act as antagonists by binding BMP ligands and preventing their interactions with signaling receptor complexes. Recombinant mouse DAN have been shown to bind BMP4 in a functional ELISA. It is likely the various DAN family members and other TGFβ BMP antagonists including Noggin, Chordin, Follistatin, and TSG can selectively antagonize the activities of different subsets of TGFβ superfamily ligands. These antagonists represent one of the many elaborate regulatory mechanisms that have evolved to control the bioactivities of the TGFβ superfamily ligands.Synonyms: DAN, DAND1, Neuroblastoma suppressor of tumorigenicity 1

ID gène: 17965

NCBI Accession: NP_032701

UniProt: Q61477