Nuclear Stain of Multiple Gene Products Including Nup62, Nup133 anticorps

N° du produit ABIN361356

Détail du produit

Antigène: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Reactivité: Saccharomyces cerevisiae

Hôte: Souris

Clonalité: Monoclonal

Application: Immunofluorescence (IF)

Specificité: Reacts with a nuclear pore complex protein.

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Protein G purified culture supernatant

Immunogène: Yeast nuclear preparations

Clone: 39C7

Isotype: IgG1

Information d'application

Indications d'application: Recommended Dilution: IF: 1:50-1:100 Quality Control: Immunofluorescence performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: total IgG fraction + 10 mM Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détail du antigène

Antigène: Nuclear Stain of Multiple Gene Products Including Nup62, Nup133

Sujet: The nuclear pore complex (NPC) is a very large structure made up of at least 50 different proteins that span the double membrane of the nuclear envelope functioning as a gateway for macromolecular traffic between the cytoplasm and the nucleus (Nakielny and Dreyfuss,1999). Discrete nuclear pore complex proteins or nucleoporins such as NUP98, NUP180 and p62 have been implicated in autoimmune disease and cancer. Patients with primary biliary cirrhosis (PBC) frequently produce autoantibodies against p62 and NUP180 (Wilken et al., 1993, Nesher et al., 2001) while NUP98 translocations have been found in patients with acute myelogenous leukemia (AML) (Jaju et al. 2001).