GABRA1 anticorps (Cytoplasmic Loop)

N° du produit ABIN361434

Détail du produit anti-GABRA1 anticorps

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Épitope: Cytoplasmic Loop

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRA1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~51k alpha1-subunit of the GABAA receptor in Western blots. Labeling is absent in alpha1-subunit knockout animals.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: bovine, canine, human, non-human primate

Purification: Antigen Affinity Purified

Immunogène: Fusion protein from the cytoplasmic loop of the alpha 1 subunit

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Détails sur GABRA1

Antigène: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Autre désignation: GABRA1 (GABRA1 Produits)

Synonymes: anticorps ECA4, anticorps EJM, anticorps EJM5, anticorps zgc:153566, anticorps Gabra-1, anticorps gamma-aminobutyric acid type A receptor alpha1 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, alpha 1, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1, anticorps gamma-aminobutyric acid receptor subunit alpha-1, anticorps GABRA1, anticorps Gabra1, anticorps gabra1, anticorps LOC100653509

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for alpha and betasubunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003). Anti-GABAA-Receptor, a1-Subunit Western blot of mouse forebrain lysates from wild type (Control) and a1-knockout ((1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a1-knockout animals.

Poids moléculaire: '51 kDa

ID gène: 29705

UniProt: P62813