MAPT anticorps (pSer416)

N° du produit ABIN361456

Détail du produit anti-MAPT anticorps

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Épitope: pSer416

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPT est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.

Réactivité croisée: Souris, Rat (Rattus)

Homologie: bovine, canine, human, non-human primate

Purification: Antigen Affinity Purified from Pooled Serum

Immunogène: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser416 conjugated to KLH

Information d'application

Indications d'application: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Stock: -20 °C

Références pour anticorps anti-MAPT (ABIN361456)

Wang, Hall, Lee, Kamgar-Parsi, Bi, Baudry: "The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation." dans: Scientific reports, Vol. 7, Issue 1, pp. 11771, (2019) (PubMed).

Détails sur MAPT

Antigène: MAPT (Microtubule-Associated Protein tau (MAPT))

Autre désignation: MAPT (MAPT Produits)

Synonymes: anticorps DDPAC, anticorps FTDP-17, anticorps MAPTL, anticorps MSTD, anticorps MTBT1, anticorps MTBT2, anticorps PPND, anticorps TAU, anticorps AI413597, anticorps AW045860, anticorps Mtapt, anticorps Tau, anticorps RNPTAU, anticorps pTau, anticorps tau, anticorps xtp, anticorps MAPT, anticorps PHF-tau, anticorps slc6a6, anticorps taut, anticorps wu:fc26e12, anticorps microtubule associated protein tau, anticorps microtubule-associated protein tau, anticorps microtubule associated protein tau S homeolog, anticorps Microtubule-associated protein tau, anticorps solute carrier family 6 (neurotransmitter transporter), member 6b, anticorps MAPT, anticorps Mapt, anticorps mapt.S, anticorps LOC5580230, anticorps CpipJ_CPIJ013260, anticorps tau, anticorps slc6a6b

Sujet: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990). Anti-Phospho-Ser416 Tau Western blot of rat brain homogenate showing specific immunolabeling of the ~59, 65, 68k Tau isoforms phosphorylated at Ser416(control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Poids moléculaire: 59/65/68 kDa

ID gène: 69329

UniProt: P19332

Pathways: Signalisation MAPK, Dynamique des Microtubules, M Phase, Regulation of Cell Size