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RAF1 anticorps (pSer259)

RAF1 Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN361884
  • Antigène Voir toutes RAF1 Anticorps
    RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
    Épitope
    • 49
    • 43
    • 35
    • 34
    • 32
    • 27
    • 24
    • 23
    • 23
    • 22
    • 19
    • 18
    • 15
    • 13
    • 13
    • 9
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer259
    Reactivité
    • 448
    • 231
    • 159
    • 14
    • 13
    • 12
    • 12
    • 9
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 479
    • 15
    • 2
    • 2
    Lapin
    Clonalité
    • 454
    • 44
    Polyclonal
    Conjugué
    • 203
    • 37
    • 28
    • 27
    • 20
    • 20
    • 20
    • 20
    • 20
    • 20
    • 17
    • 16
    • 10
    • 10
    • 10
    • 10
    • 10
    Cet anticorp RAF1 est non-conjugé
    Application
    • 298
    • 217
    • 105
    • 104
    • 89
    • 75
    • 49
    • 31
    • 30
    • 24
    • 16
    • 11
    • 10
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    The antibody detects endogenous level of Raf-1 only when phosphorylated at serine 259.
    Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site.
    Immunogène
    Peptide sequence around phosphorylation site of pSer259 (S-T-S (p) -T-P) derived from Human Raf1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
    Isotype
    IgG
    Top Product
    Discover our top product RAF1 Anticorps primaire
  • Indications d'application
    Western blotting: 1:500-1:1000
    Immunohistochemistry: 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Qiu, Wang, Han, Liu, Huang, Altaf, Qiu, Javed, Zheng, Chen, Li: "Prognostic impact of Raf-1 and p-Raf-1 expressions for poor survival rate in non-small cell lung cancer." dans: Cancer science, Vol. 103, Issue 10, pp. 1774-9, (2012) (PubMed).

  • Antigène
    RAF1 (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
    Autre désignation
    Raf1 (RAF1 Produits)
    Synonymes
    anticorps CRAF, anticorps NS5, anticorps Raf-1, anticorps c-Raf, anticorps c-raf, anticorps craf, anticorps raf1, anticorps RAF1, anticorps 6430402F14Rik, anticorps AA990557, anticorps BB129353, anticorps Craf1, anticorps D830050J10Rik, anticorps v-Raf, anticorps raf, anticorps cRaf, anticorps Raf-1 proto-oncogene, serine/threonine kinase, anticorps Raf-1 proto-oncogene, serine/threonine kinase a, anticorps v-raf-leukemia viral oncogene 1, anticorps Raf-1 proto-oncogene, serine/threonine kinase S homeolog, anticorps RAF1, anticorps Raf1, anticorps raf1a, anticorps raf1, anticorps raf1.S
    Sujet
    Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.
    Poids moléculaire
    73 kDa
    UniProt
    P04049
    Pathways
    Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling, BCR Signaling
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