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MEK1 anticorps (pThr291)
MAP2K1
Reactivité: Humain, Souris, Rat
WB
Hôte: Lapin
Polyclonal
unconjugated
Détail du produit anti-MEK1 anticorps
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Antigène
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MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Épitope
Tous les épitopes à travers MEK1 Anticorps.
pThr291
Reactivité
Toutes les réactivités sur MEK1 Anticorps
Humain, Souris, Rat
Hôte
Toutes les hôtes sur MEK1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur MEK1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers MEK1 Anticorps
Cet anticorp MEK1 est non-conjugé
Application
Tous les applications à travers MEK1 Anticorps.
Western Blotting (WB)
Specificité
The antibody detects endogenous level of MEK1 only when phosphorylated at threonine 291.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Immunogène
Peptide sequence around phosphorylation site of pThr291 (P-R-T (p) -P-G derived from Human MEK1. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.
Isotype
IgG
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Information d'application
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Indications d'application
Western blotting: 1:500-1:1000
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
1 mg/mL
Buffer
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C/-20 °C
Stockage commentaire
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Références pour anticorps anti-MEK1 (ABIN362382)
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Xu, Zhao, Huang, Ding, Wang, Wang, Cheng, Kang, Wang : "CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. " dans: The journal of gene medicine , Vol. 12 , Issue 1 , pp. 97-106 , (2010 ) (PubMed ).
Ikari, Atomi, Kinjo, Sasaki, Sugatani : "Magnesium deprivation inhibits a MEK-ERK cascade and cell proliferation in renal epithelial Madin-Darby canine kidney cells. " dans: Life sciences , Vol. 86 , Issue 19-20 , pp. 766-73 , (2010 ) (PubMed ).
Détails sur MEK1
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Antigène
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
Autre désignation
MEK1 (MAP2K1 Produits )
Synonymes
anticorps Mek1, anticorps CFC3, anticorps MAPKK1, anticorps MEK1, anticorps MKK1, anticorps PRKMK1, anticorps MEKK1, anticorps Prkmk1, anticorps mek-2, anticorps si:ch211-242m18.2, anticorps wu:fj56a12, anticorps wu:fj61b01, anticorps zgc:56557, anticorps ATMEK1, anticorps F20B18.180, anticorps F20B18_180, anticorps MAP kinase/ ERK kinase 1, anticorps MITOGEN ACTIVATED PROTEIN KINASE KINASE, anticorps MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, anticorps NMAPKK, anticorps MEK, anticorps mitogen activated protein kinase kinase 1, anticorps mitogen-activated protein kinase kinase 1, anticorps mitogen-activated protein kinase kinase 1 L homeolog, anticorps MAP kinase/ ERK kinase 1, anticorps Map2k1, anticorps MAP2K1, anticorps map2k1.L, anticorps map2k1, anticorps MEK1
Sujet
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
Poids moléculaire
45 kDa
NCBI Accession
NP_002746
UniProt
Q02750
Pathways
Signalisation MAPK , Signalisation RTK , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagy , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
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