SKIL anticorps (AA 600-684)

N° du produit ABIN372440

Détail du produit anti-SKIL anticorps

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Épitope: AA 600-684

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SKIL est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody recognizes SnoN.

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogène: Synthetic peptide corresponding to a portion of the amino acids 600-684 of human SnoN.

Isotype: IgG

Information d'application

Indications d'application: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Détails sur SKIL

Antigène: SKIL (SKI-Like Oncogene (SKIL))

Autre désignation: SKIL / SnoN (SKIL Produits)

Synonymes: anticorps SNO, anticorps SnoA, anticorps SnoI, anticorps SnoN, anticorps Skir, anticorps Sno, anticorps SKIL, anticorps DKFZp459L122, anticorps sno, anticorps zgc:193698, anticorps SKI like proto-oncogene, anticorps SKI-like proto-oncogene, anticorps ski-like protein, anticorps SKI-like, anticorps SKI-like proto-oncogene b, anticorps SKIL, anticorps Skil, anticorps LOC100010058, anticorps skil, anticorps skilb

Sujet: SnoN, an 80 KDa protein, is a member of ski family of nuclear proto-oncogenes involved in regulation of cellular transformation and differentiation. Primarily expressed in two isoforms, SnoN is localized in cytoplasm in normal tissues and non-tumorigenic primary epithelial cells. In cancer tissues or cells, SnoN is exclusively localized in the nucleus. It plays a vital role in inhibition of cell cycle arrest induced by TGF-. Upon morphological differentiation or cell-cycle arrest, SnoN translocates into the nucleus, binds to Smad2, Smad3, and Smad4 on TGF- -responsive promoters and represses their ability to activate expression of TGF- target genes. It has also been found to mediate transcriptional repression of thyroid hormone receptor, Mad and pRb. Increased expression of SnoN has been detected in many human tumor cell lines suggesting a clinical significance.Synonyms: SNO, Ski-like protein, Ski-related novel protein N, Ski-related oncogene, Ski-related protein, SnoA, Snol

Poids moléculaire: 77 kDa.

ID gène: 6498

NCBI Accession: NP_001138569

UniProt: P12757

Pathways: Positive Regulation of Response to DNA Damage Stimulus