GABRA1
Reactivité: Rat
WB, IHC, ICC, IF
Hôte: Souris
Monoclonal
S399-19
PE
Indications d'application
Western Blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
-20 °C
Stockage commentaire
Store the antibody undiluted (in aliquots) at-20 °C.
Chugh, Ali, Bakochi, Bahonjic, Etholm, Ekdahl: "Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2." dans: PLoS ONE, Vol. 10, Issue 7, pp. e0132366, (2015) (PubMed).
Marowsky, Rudolph, Fritschy, Arand: "Tonic inhibition in principal cells of the amygdala: a central role for ?3 subunit-containing GABAA receptors." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 25, pp. 8611-9, (2012) (PubMed).
Goffin, Ali, Rampersaud, Harkavyi, Fuchs, Whitton, Nairn, Jovanovic: "Dopamine-dependent tuning of striatal inhibitory synaptogenesis." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 8, pp. 2935-50, (2010) (PubMed).
Antigène
GABRA1
(gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABA A receptor subunit alpha-1, GABRA-1, Gamma-aminobutyric acid receptor subunit alpha-1