GABRB2 anticorps (Cytoplasmic Loop)

N° du produit ABIN372637

Détail du produit anti-GABRB2 anticorps

Antigène: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Épitope: Cytoplasmic Loop

Reactivité: Humain, Rat, Souris, Chien, Non-Human Primate

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GABRB2 est non-conjugé

Application: Western Blotting (WB)

Specificité: Specific for the ~55k Beta-2 subunit of the GABAA Receptor in Western blots.

Réactivité croisée (Details): Species reactivity (expected):Human, Canine, Chicken, Mouse and non-Human Primates.
Species reactivity (tested):Rat.

Purification: Affinity Chromatography.

Immunogène: Fusion protein from the cytoplasmic loop of the Beta-2 subunit of Rat GABAA Receptor.

Isotype: IgG

Information d'application

Indications d'application: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody undiluted (in aliquots) at-20 °C.

Détails sur GABRB2

Antigène: GABRB2 (gamma-aminobutyric Acid (GABA) A Receptor, beta 2 (GABRB2))

Autre désignation: GABRB2 (GABRB2 Produits)

Synonymes: anticorps GABRB2, anticorps GARB2, anticorps fj59e04, anticorps gabaabeta2, anticorps wu:fj59e04, anticorps zgc:136311, anticorps GABARB, anticorps AI834970, anticorps C030002O17Rik, anticorps C030021G16Rik, anticorps Gabrab2, anticorps Gabrb-2, anticorps gamma-aminobutyric acid type A receptor beta2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, beta 2, anticorps gamma-aminobutyric acid type A receptor beta 2 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit beta 2, anticorps GABRB2, anticorps gabrb2, anticorps Gabrb2

Sujet: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABA A receptor subunit beta-2, GABRB-2, Gamma-aminobutyric acid receptor subunit beta-2

ID gène: 25451

NCBI Accession: NP_037089

UniProt: P63138

Pathways: Sensory Perception of Sound, Synaptic Membrane