SORL1 anticorps (C-Term)

N° du produit ABIN374076

Détail du produit anti-SORL1 anticorps

Antigène: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp SORL1 est non-conjugé

Application: Western Blotting (WB)

Séquence: C-TGFSDDVPMV IA

Specificité: This antibody detects Sortilin-Related Receptor at C-term.

Réactivité croisée (Details): Species reactivity (expected):Human, Rat, Canine (Dog), Bovine.
Species reactivity (tested):Mouse.

Purification: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogène: Peptide from the C Terminus of the protein according to NP_003096.1. Genename: SORL1

Information d'application

Indications d'application: Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.3-1 μg/mL. Approx 250 kDa band observed in Mouse and Rat Brain lysates(calculated MW of 240 kDa according to Human NP_003096.1, and 240 kDa accordnig toMouse NP_035566.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur SORL1

Antigène: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Autre désignation: Sortilin-Related Receptor (SORL1) (SORL1 Produits)

Synonymes: anticorps SORL1, anticorps C11orf32, anticorps LR11, anticorps LRP9, anticorps SORLA, anticorps SorLA-1, anticorps gp250, anticorps SorLA, anticorps 2900010L19Rik, anticorps AI596264, anticorps AW261561, anticorps mSorLA, anticorps Lr11, anticorps RGD619914, anticorps sortilin related receptor 1, anticorps sortilin-related receptor, anticorps sortilin-related receptor, L(DLR class) A repeats containing, anticorps sortilin-related receptor, L(DLR class) A repeats-containing, anticorps sortilin-related receptor, LDLR class A repeats-containing, anticorps sorl1, anticorps LOC582560, anticorps SORL1, anticorps Sorl1

Sujet: Sortilin-related receptor (SORL1) is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole, low expression in the putamen and the thalamus. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.Synonyms: LR11, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, SorLA, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats

ID gène: 6653

NCBI Accession: NP_003096

UniProt: Q92673

Pathways: Smooth Muscle Cell Migration